Contributions of Histone Variants in Nucleosome Structure and Function

被引：64

作者：

Kurumizaka, Hitoshi ^{[1
]}

Kujirai, Tomoya ^{[1
]}

Takizawa, Yoshimasa ^{[1
]}

机构：

[1] Univ Tokyo, Inst Quantitat Biosci, Lab Chromatin Struct & Funct, Bunkyo Ku, 1-1-1 Yayoi, Tokyo 1130032, Japan

来源：

JOURNAL OF MOLECULAR BIOLOGY | 2021年 / 433卷 / 06期

关键词：

epigenetics; chromatin; nucleosome; histone variant; structure; CENP-A NUCLEOSOME; CRYO-EM STRUCTURE; CRYSTAL-STRUCTURE; CORE PARTICLE; H3; VARIANTS; CENTROMERIC NUCLEOSOME; H2A.Z NUCLEOSOMES; CHROMATIN PROTEIN; DNA METHYLATION; TRANSCRIPTION;

D O I：

10.1016/j.jmb.2020.10.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chromatin compacts genomic DNA in eukaryotes. The primary chromatin unit is the nucleosome core particle, composed of four pairs of the core histones, H2A, H2B, H3, and H4, and 145-147 base pairs of DNA. Since replication, recombination, repair, and transcription take place in chromatin, the structure and dynamics of the nucleosome must be versatile. These nucleosome characteristics underlie the epigenetic regulation of genomic DNA. In higher eukaryotes, many histone variants have been identified as non-allelic isoforms, which confer nucleosome diversity. In this article, we review the manifold types of nucleosomes produced by histone variants, which play important roles in the epigenetic regulation of chromatin. (C) 2020 The Author(s). Published by Elsevier Ltd.

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页数：16

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