Comparative study of cardioprotective and antiradical activity of estrogens and their nitro derivatives

被引：0

作者：

Matyushin, AI ^{[1
]}

Balaban'yan, VY ^{[1
]}

Rzheznikov, VM ^{[1
]}

Mambetova, AZ ^{[1
]}

机构：

[1] Russian State Med Univ, Medicobiol Fac, Dept Mol Pharmacol & Radiobiol, Moscow 117437, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1999年 / 128卷 / 10期

关键词：

antiradical activity; nitro estrogens; experimental myocardial infarction;

D O I：

10.1007/BF02433191

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cardioprotective and antiradical activities of estrogens and their nitro derivatives are compared. Antiradical activity was observed in estradiol, ethanol estradiol, and estradiol nitrate, but not in nystranol, which exhibited antiradical properties only after acid hydrolysis. The data obtained on hearts from rats with experimental myocardial infarction show that estrogens and their nitro derivatives restrict the area of myocardial infarction due to antiischemic and/or antinecrotic activities.

引用

页码：1009 / 1011

页数：3

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