Simulating folding of helical proteins with coarse grained models

被引：0
作者：
Takada, S [1 ]
机构：
[1] Kobe Univ, Dept Chem, Kobe, Hyogo 6578501, Japan
来源：
PROGRESS OF THEORETICAL PHYSICS SUPPLEMENT | 2000年 / 138期
关键词：
D O I：
暂无
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
We describe how potential parameters in a coarse graind model of proteins can be optimized with use of available protein three dimensional database. With this optimized potentials, we simulated a three helix bundle protein and found that all trajectories reach at the native structure within 1 microsecond. Interestingly, a quasi-mirror image is successfully discriminated from the native topology.
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收藏
页码：366 / 371
页数：6
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