Evolution of Carbapenem-Resistant Serotype K1 Hypervirulent Klebsiella pneumoniae by Acquisition of blaVIM-1-Bearing Plasmid

被引：26

作者：

Dong, Ning ^{[1
,2
]}

Sun, Qiaoling ^{[3
]}

Huang, Yonglu ^{[3
]}

Shu, Lingbin ^{[3
]}

Ye, Lianwei ^{[1
,2
]}

Zhang, Rong ^{[3
]}

Chen, Sheng ^{[1
,2
]}

机构：

[1] Hong Kong PolyU Shen Zhen Res Inst, Food Safety & Technol Res Ctr, Shenzhen Key Lab Food Biol Safety Control, Shenzhen, Peoples R China

[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, State Key Lab Chirosci, Hung Hom,Kowloon, Hong Kong, Peoples R China

[3] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Clin Lab, Hangzhou, Zhejiang, Peoples R China

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2019年 / 63卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Klebsiella pneumoniae; VIM; carbapenem resistance; hypervirulence;

D O I：

10.1128/AAC.01056-19

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report the identification of a carbapenem-resistant, hypervirulent Klebsiella pneumoniae (hvKp) strain which produced the carbapenemase VIM-1. Genomic analysis showed that the strain belonged to sequence type ST23 and serotype K1, a major hvKp clone, and harbored three resistance-encoding plasmids. Among them, a bla(VIM-1)-bearing plasmid was found to possess a mosaic structure presumably generated by multiple gene mobilization events. This finding indicates that hvKp actively acquires mobile resistance-encoding elements, facilitating simultaneous expression of hypervirulence and carbapenem-resistance.

引用

页数：5

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