Tissue tropism of Saint Louis encephalitis virus: Histopathology triggered by epidemic and non-epidemic strains isolated in Argentina

被引：5

作者：

Elisa Rivarola, Maria ^{[1
,2
]}

Albrieu-Llinas, Guillermo ^{[1
,2
]}

Belen Pisano, Maria ^{[1
,2
]}

Beatriz Tauro, Laura ^{[1
,2
]}

Gorosito-Serran, Melisa ^{[2
,3
]}

Gabriel Beccaria, Cristian ^{[2
,3
]}

Adrian Diaz, Luis ^{[1
,2
]}

Vazquez, Ana ^{[2
,4
,5
]}

Quaglia, Agustin ^{[1
,2
]}

Lopez, Cristina ^{[2
,6
]}

Spinsanti, Lorena ^{[1
,2
]}

Gruppi, Adriana ^{[2
,3
]}

Silvia Contigiani, Marta ^{[1
,2
]}

机构：

[1] Univ Nacl Cordoba, Fac Ciencias Med, Inst Virol Dr JM Vanella, Lab Arbovirus, Enfermera Gordillo Gomez S-N,Ciudad Univ, RA-5016 Cordoba, Argentina

[2] Univ Nacl Cordoba, CONICET, Inst Invest Biol & Tecnol, Av Velez Sarfield 1611, RA-5016 Cordoba, Argentina

[3] Natl Univ Cordoba, Fac Ciencias Quim, Dept Bioquim Clin, Inmunol, Av Medina Allende & Haya Torre, RA-5016 Cordoba, Argentina

[4] Inst Salud Carlos III, Carretera Majadahonda Pozuelo,Km 2-200, Majadahonda 28220, Madrid, Spain

[5] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain

[6] Univ Nacl Cordoba, Fac Ciencias Med, Inst Biol Celular, Juan Filloy S-N,Ciudad Univ, Cordoba, Argentina

来源：

VIROLOGY | 2017年 / 505卷

关键词：

Arbovirus; Saint Louis encephalitis virus; Tissue tropism; Histopathology; Pathogenesis; WEST-NILE-VIRUS; CENTRAL-NERVOUS-SYSTEM; TICK-BORNE ENCEPHALITIS; CD8(+) T-CELLS; JAPANESE ENCEPHALITIS; VIRULENCE VARIATION; MOLECULAR-BASIS; INFECTION; MOUSE; PATHOGENESIS;

D O I：

10.1016/j.virol.2017.02.023

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Saint Louis encephalitis virus (SLEV) reemerged in South America, and caused encephalitis outbreaks at the beginning of the 21st century. To enhance our knowledge about SLEV virulence, we performed comparative pathogenesis studies in Swiss albino mice inoculated with two different variants, the epidemic strain CbaAr4005 and the non-epidemic strain CorAn-9275. Only the infection of mice with SLEV strain CbaAr-4005 resulted in high viremia, invasion of peripheral tissues including the lungs, kidney, and spleen, and viral neuroinvasion. This was associated with inflammatory pathology in the lungs, spleen, and brain as well as morbidity and mortality. In contrast, neither signs of desease nor viral replication were observed in mice infected with strain CorAn-9275. Interestingly, important loss of B cells and development of altered germinal centers (GC) were detected in the spleen of mice infected with strain CbaAr-4005, whereas mice infected with SLEV CorAn-9275 developed prominent GC with conserved follicular architecture, and neutralizing antibodies.

引用

页码：181 / 192

页数：12

共 82 条

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