Microstructured Surfaces Cause Severe but Non-Detrimental Deformation of the Cell Nucleus

被引：105
作者：
Davidson, Patricia M. [1 ]
Ozcelik, Hayriye [2 ]
Hasirci, Vasif [2 ]
Reiter, Guenter [3 ]
Anselme, Karine [1 ]
机构：
[1] Univ Haute Alsace, CNRS, LRC 7228, Inst Sci Mat Mulhouse, F-68057 Mulhouse, France
[2] BIOMAT, Dept Biol Sci, METU, Biotechnol Res Unit, TR-06531 Ankara, Turkey
[3] Univ Freiburg, Inst Phys, D-79104 Freiburg, Germany
来源：
ADVANCED MATERIALS | 2009年 / 21卷 / 35期
关键词：
DIFFERENTIATION; PROLIFERATION; DEFORMABILITY; FIBROBLASTS; ALIGNMENT; LINES;
D O I：
10.1002/adma.200900582
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Surface features on the length scale of organelles allow their manipulation. Here, we present observations of an unexpected deformation of nuclei within cells growing on surfaces with micrometer-sized pillars. Our results demonstrate that a microstructured surface can induce strong shape deformations in cells, without harmful consequences, and strongly suggest that these are limited to cancerous cells.
引用
收藏
页码：3586 / +
页数：6
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