Current theories on the pathophysiology of multiple organ failure after trauma

被引：117

作者：

Tsukamoto, Takeshi ^{[1
]}

Chanthaphavong, R. Savanh ^{[2
]}

Pape, Hans-Christoph ^{[1
]}

机构：

[1] Univ Pittsburgh, Med Ctr, Dept Orthopaed Surg, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Med Ctr, Dept Med Gastroenterol, Pittsburgh, PA USA

来源：

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED | 2010年 / 41卷 / 01期

关键词：

Multiple organ failure (MOF); Pathophysiology after trauma; Systemic inflammatory response syndrome (SIRS); Inflammation; Cytokines; TUMOR-NECROSIS-FACTOR; RESPIRATORY-DISTRESS-SYNDROME; ISCHEMIA-REPERFUSION INJURY; SHOCK MESENTERIC LYMPH; INFLAMMATORY RESPONSE SYNDROME; ABDOMINAL COMPARTMENT SYNDROME; INTESTINAL BARRIER FUNCTION; CYTOKINE-GENERATING ORGAN; MOBILITY-GROUP PROTEIN-1; NITRIC-OXIDE REGULATION;

D O I：

10.1016/j.injury.2009.07.010

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Despite the enormous efforts to elucidate the mechanisms of the development of multiple organ failure (MOF) following trauma, MOF following trauma is still a leading cause of late post-injury death and morbidity. Now, it has been proven that excessive systemic inflammation following trauma participates in the development of MOF. Fundamentally, the inflammatory response is a host-defence response; however, on occasion, this response turns around to cause deterioration to host depending on exo- and endogenic factors. Through this review we aim to describe the pathophysiological approach for MOF after trauma studied so far and also introduce the prospects of this issue for the future. Published by Elsevier Ltd.

引用

页码：21 / 26

页数：6

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