Rethinking phosphatidylinositol 3-monophosphate

被引：41

作者：

Falasca, Marco ^{[1
]}

Maffucci, Tania ^{[1
]}

机构：

[1] Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst Cell & Mol Sci, Ctr Diabet,Inositide Signalling Grp, London E1 2AT, England

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2009年 / 1793卷 / 12期

关键词：

Autophagy; Myotubularin; mTOR; Phosphoinositide; 3-kinase; Rab5; II PHOSPHOINOSITIDE 3-KINASE; PLECKSTRIN HOMOLOGY DOMAIN; ISOLATED RAT HEPATOCYTES; PIK3C3 PROMOTER VARIANT; FLUORESCENCE MICROSCOPY; CAENORHABDITIS-ELEGANS; 3-PHOSPHATE PTDINS(3)P; PHAGOSOME MATURATION; SIGNALING PATHWAY; HIGHER EUKARYOTES;

D O I：

10.1016/j.bbamcr.2009.10.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A generally accepted view considers phosphatidylinositol 3-monophosphate (PtdIns3P) as a lipid confined to the endosomal compartment where it regulates trafficking pathways and is produced constitutively and exclusively by class III phosphoinositide 3-kinase (PI3K). Recent evidence suggests that this phosphoinositide has a more complex role as a second messenger involved in different physiological and pathological events and that specific intracellular localization of kinases and/or phosphatases is critical for PtdIns3P synthesis and PtdIns3P-dependent intracellular functions. Here, we review the current knowledge of the regulation and function of PtdIns3P and discuss how the view of PtdIns3P changed in the last few years. (C) 2009 Elsevier B.V. All rights reserved.

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收藏

页码：1795 / 1803

页数：9

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