Structures of cribochalines A and B, branched-chain methoxylaminoalkyl pyridines from the micronesian sponge, Cribochalina sp absolute configuration and enantiomeric purity of related O-methyl oximes

被引：31

作者：

Nicholas, GM ^{[1
]}

Molinski, TF ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

来源：

TETRAHEDRON | 2000年 / 56卷 / 19期

基金：

美国国家卫生研究院;

关键词：

alkaloid; oxidation; Porifera;

D O I：

10.1016/S0040-4020(00)00189-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new 3-alkyl pyridines, cribochalines A (2) and B (3), were isolated from the North Pacific sponge Cribochalina sp. The known related oxime, ikimine A, was shown to be a 2.8:1 mixture of the (S)- and (R)-enantiomers. Cribochaline A exhibited antifungal activity against Candida albicans ATCC and Fluconazole-resistant strains C. albicans 96-489, C. krusei and C. glabrata. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2921 / 2927

页数：7

共 9 条

[1] 4 BETA-ALKYLPYRIDINES FROM A SPONGE [J].