Human umbilical cord mesenchymal stem cells derived-exosomes in diseases treatment

被引：204
作者：
Yaghoubi, Yoda [1 ,2 ]
Movassaghpour, AliAkbar [3 ]
Zamani, Majid [4 ]
Talebi, Mehdi [3 ]
Mehdizadeh, Amir [6 ]
Yousefi, Mehdi [1 ,5 ,6 ]
机构：
[1] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran
[2] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran
[3] Tabriz Univ Med Sci, Hematol & Oncol Res Ctr, POB 51665-158, Tabriz, Iran
[4] Tabriz Univ Med Sci, Dept Immunol, POB 6446-14155, Tabriz, Iran
[5] Tabriz Univ Med Sci, Aging Res Inst, Tabriz, Iran
[6] Tabriz Univ Med Sci, Endocrine Res Ctr, Tabriz, Iran
来源：
LIFE SCIENCES | 2019年 / 233卷
关键词：
Exosome; Human umbilical cord; Mesenchymal stem cells; Clinical application; VERSUS-HOST-DISEASE; INFLAMMATORY-BOWEL-DISEASE; AMYLOID-BETA-PEPTIDE; STROMAL CELLS; ALZHEIMERS-DISEASE; PROTEOMIC ANALYSIS; NERVOUS-SYSTEM; INJURY; CISPLATIN; PROTEINS;
D O I：
10.1016/j.lfs.2019.116733
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Exosomes are extracellular vesicles with the size of 40-100 nm in diameter and a density of 1.13-1.19 g/mL, containing proteins, mRNAs, miRNAs, and DNAs. Exosomes change the recipient cells biochemical features through biomolecules delivery and play a role in cellular communication. These vesicles are produced from body fluids and different cell types like mesenchymal stem cells (MSCs). Evidence suggests that mesenchymal stem cells-derived exosome (MSC-EXO) exhibit functions similar to MSCs with low immunogenicity and no tumorization. MSCs can also be isolated from a variety of sources including human umbilical cord (HUC). Because of the non-invasive collection method, higher proliferation and lower immunogenicity, HUCMSC-EXO has been frequently used in regenerative medicine and various diseases treatment compared to the other MSC-EXO resources. This review aimed to investigate the applications of HUCMSC-EXO in different diseases.
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页数：10
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