Structural insights into the signal recognition particle

被引：103

作者：

Doudna, JA ^{[1
]}

Batey, RT

机构：

[1] Univ Calif Berkeley, Howard Hughes Med Inst, Dept Mol & Cell Biol, Berkeley, CA 94705 USA

[2] Univ Calif Berkeley, Howard Hughes Med Inst, Dept Chem, Berkeley, CA 94705 USA

[3] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA

来源：

ANNUAL REVIEW OF BIOCHEMISTRY | 2004年 / 73卷

关键词：

SRP; signal sequence; SRP54; SRP19; SRP receptor; SRP RNA;

D O I：

10.1146/annurev.biochem.73.011303.074048

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The signal recognition particle (SRP) directs integral membrane and secretory proteins to the cellular protein translocation machinery during translation. The SRP is an evolutionarily conserved RNA-protein complex whose activities are regulated by GTP hydrolysis. Recent structural investigations of SRP functional domains and interactions provide new insights into the mechanisms of SRP activity in all cells, leading toward a comprehensive understanding of protein trafficking by this elegant pathway.

引用

页码：539 / 557

页数：19

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