Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats

被引：15

作者：

Farjah, Gholam Hossein ^{[1
]}

Salehi, Shadi ^{[2
]}

Ansari, Mohammad Hasan ^{[3
]}

Pourheidar, Bagher ^{[1
]}

机构：

[1] Urmia Univ Med Sci, Dept Anat, Neurophysiol Res Ctr, Fac Med, Orumiyeh, Iran

[2] Urmia Univ Med Sci, Fac Med, Orumiyeh, Iran

[3] Urmia Univ Med Sci, Dept Biochem, Fac Med, Orumiyeh, Iran

来源：

IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES | 2017年 / 20卷 / 03期

关键词：

Ischemia; Reperfusion; Spinal cord; Saffron extract; ISCHEMIA/REPERFUSION INJURY; CONSTITUENT; INFLAMMATION; ANTIOXIDANT;

D O I：

10.22038/IJBMS.2017.8364

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Objective(s): Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury. Materials and Methods: Thirty five male Sprague-Dawley rats were divided into 5 groups: intact, sham surgery, normal saline (NS), low dose saffron aqua extract, high dose saffron aqua extract. Results: The mean motor deficit index (MDI) scores were significantly lower in the saffron extract groups than in the NS group at 48 hr after spinal cord ischemia (P<0.001). Saffron extract groups significantly decreased plasma level of malondialdehyde than in the NS Group (P<0.05). The number of motor normal neurons was significantly greater in the high saffron extract group than in the NS and low saffron group (P<0.05). Conclusion: These data suggest that a saffron extract may protect spinal cord neurons from I/R injury.

引用

页码：334 / 337

页数：4

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