How Tat targets TAR: Structure of the BIV peptide RNA complex

被引：23
|
作者：
Greenbaum, NL
机构：
[1] Dept. Biochem. and Molec. Biophys., Columbia University, College of Physicians and Surgeons, New York, NY 10032
来源：
STRUCTURE | 1996年 / 4卷 / 01期
关键词：
D O I：
10.1016/S0969-2126(96)00003-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two new NMR structures describing the complex formed by a peptide from the BIV Tat protein with the TAR RNA provide a significant advance in our understanding of the ways in which peptides interact with specific sites in the major groove of their RNA targets.
引用
收藏
页码：5 / 9
页数：5
相关论文
共 50 条
  • [41] INHIBITION OF AN HIV-1 TAT-DERIVED PEPTIDE BINDING TO TAR RNA BY AMINOGLYCOSIDE ANTIBIOTICS
    MEI, HY
    GALAN, AA
    HALIM, NS
    MACK, DP
    MORELAND, DW
    SANDERS, KB
    TRUONG, HN
    CZARNIK, AW
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (22) : 2755 - 2760
  • [42] Realtime detection of HIV-1 TAR RNA/Tat peptide interactions by acoustic wave biosensor
    Thompson, M
    Su, HB
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1996, 212 : 80 - IEC
  • [43] RNA bulge entropies in the unbound state correlate with peptide binding strengths for HIV-1 and BIV TAR RNA because of improved conformational access
    Lustig, B
    Bahar, I
    Jernigan, RL
    NUCLEIC ACIDS RESEARCH, 1998, 26 (22) : 5212 - 5217
  • [44] EFFICIENT TRANSACTIVATION BY THE HIV-2 TAT PROTEIN REQUIRES A DUPLICATED TAR RNA STRUCTURE
    BERKHOUT, B
    GATIGNOL, A
    SILVER, J
    JEANG, KT
    NUCLEIC ACIDS RESEARCH, 1990, 18 (07) : 1839 - 1846
  • [45] DUAL-SPECIFICITY INTERACTION OF HIV-1 TAR RNA WITH TAT PEPTIDE-OLIGONUCLEOTIDE CONJUGATES
    TUNG, CH
    WANG, JH
    LEIBOWITZ, MJ
    STEIN, S
    BIOCONJUGATE CHEMISTRY, 1995, 6 (03) : 292 - 295
  • [46] Inhibition of HIV-1 TAR RNA-Tat peptide complexation using poly(acrylic acid)
    Zhao, H
    Li, JR
    Jiang, L
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 320 (01) : 95 - 99
  • [47] Characterization of the solution conformations of unbound and Tat peptide-bound forms of HIV-1 TAR RNA
    Long, KS
    Crothers, DM
    BIOCHEMISTRY, 1999, 38 (31) : 10059 - 10069
  • [48] Identification of amino acids that promote specific and rigid TAR RNA-tat protein complex formation
    Edwards, TE
    Robinson, BH
    Sigurdsson, ST
    CHEMISTRY & BIOLOGY, 2005, 12 (03): : 329 - 337
  • [49] Quantitative study of HIV-1 Tat peptide and TAR RNA interaction inhibited by poly(allylamine hydrochloride)
    Zhao, H
    Dai, DS
    Li, JR
    Chen, Y
    Jiang, L
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 312 (02) : 351 - 354
  • [50] Recognition of HIV-1 TAR RNA by Tat protein and Tat-derived peptides
    Aboul-ela, F
    Varani, G
    THEOCHEM-JOURNAL OF MOLECULAR STRUCTURE, 1998, 423 (1-2): : 29 - 39
12345