Matrix Metalloproteinase-2 Gene Variants and Abdominal Aortic Aneurysm

被引：12
|
作者：
Smallwood, L. [1 ]
Warrington, N. [2 ]
Allcock, R. [3 ]
van Bockxmeer, F. [3 ]
Palmer, L. J. [2 ]
Iacopetta, B. [1 ]
Golledge, J. [4 ]
Norman, P. E. [1 ]
机构：
[1] Univ Western Australia, Sch Surg, Fremantle Hosp, Fremantle, WA 6959, Australia
[2] Univ Western Australia, Ctr Genet Epidemiol & Biostat, Fremantle, WA 6959, Australia
[3] Univ Western Australia, Sch Pathol & Lab Med, Fremantle, WA 6959, Australia
[4] James Cook Univ, Vasc Biol Unit, Sch Med, Townsville, Qld 4811, Australia
来源：
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY | 2009年 / 38卷 / 02期
基金：
英国医学研究理事会;
关键词：
Abdominal aortic aneurysm; Expansion; Matrix metalloproteinase-2; Genetic association study; POLYMORPHISMS;
D O I：
10.1016/j.ejvs.2009.04.019
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Objective: To investigate associations between two polymorphisms of the matrix metalloproteinase-2 gene (MMP2) and the incidence and progression of abdominal aortic aneurysm (AAA). Methods: Cases and controls were recruited from a trial of screening for AAAs. The association between two variants of MMP2 (-1360C > T, and +649C > T) in men with AAA (n = 678) and in controls (n = 659) was examined using multivariate analyses. The association with AAA expansion (n = 638) was also assessed. Results: In multivariate analyses with adjustments for multiple testing, no association between either SNP and AAA presence or expansion was detected. Conclusion: MMP2 -1360C > T and +649C > T variants are not risk factors for AAA. (c) 2009 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：169 / 171
页数：3
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