Fast high-resolution J-resolved correlation spectroscopy in inhomogeneous fields

Multi-dimensional NMR spectroscopy alleviates the jam or even overlaps of peaks in one-dimensional spectra of complicated samples, extending the application of NMR spectroscopy. However, the acquisition of high-resolution NMR spectra relies on high homogeneity of magnetic field, which is difficult to achieve in many cases. In this study, we present a fast NMR approach for acquiring high-resolution 3D spectrum in inhomogeneous fields via intermolecular zero-quantum coherence and spatial encoding technique, providing J-resolved spectrum and correlation spectrum information simultaneously within the acquisition time scale for a conventional two-dimensional spectrum. (C) 2014 Elsevier B.V. All rights reserved.