Therapeutic Targeting of Notch Signaling Pathway in Hematological Malignancies

被引：29

作者：

Sorrentino, Claudia ^{[1
]}

Cuneo, Antonio ^{[1
,2
]}

Roti, Giovanni ^{[1
]}

机构：

[1] Univ Parma, Dept Med & Surg, I-43126 Parma, Italy

[2] Univ Ferrara, Dept Med Sci, I-44121 Ferrara, Italy

来源：

MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES | 2019年 / 11卷

关键词：

NOTCH1; Targeted therapy; T-cell acute lymphoblastic leukemia; Chronic lymphocytic leukemia; Mantle cell lymphoma; PROTEASOME INHIBITOR BORTEZOMIB; GAMMA-SECRETASE INHIBITORS; MANTLE-CELL LYMPHOMA; ACUTE LYMPHOBLASTIC-LEUKEMIA; T-CELL; B-CLL; ACTIVATING MUTATIONS; MONOCLONAL-ANTIBODY; TUMOR-GROWTH; APOPTOSIS;

D O I：

10.4084/MJHID.2019.037

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The Notch pathway plays a key role in several processes, including stem-cell self-renewal, proliferation, and cell differentiation. Several studies identified recurrent mutations in hematological malignancies making Notch one of the most desirable targets in leukemia and lymphoma. The Notch signaling mediates resistance to therapy and controls cancer stem cells supporting the development of on-target therapeutic strategies to improve patients' outcome. In this brief review, we outline the therapeutic potential of targeting Notch pathway in T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and mantle cell lymphoma.

引用

页数：13

共 119 条

[1] Therapeutic antibody targeting of Notch1 in T-acute lymphoblastic leukemia xenografts [J].

Agnusdei, V. ;

Minuzzo, S. ;

Frasson, C. ;

Grassi, A. ;

Axelrod, F. ;

Satyal, S. ;

Gurney, A. ;

Hoey, T. ;

Seganfreddo, E. ;

Basso, G. ;

Valtorta, S. ;

Moresco, R. M. ;

Amadori, A. ;

Indraccolo, S. .

LEUKEMIA, 2014, 28 (02) :278-288

[2] Combination bortezomib and rituximab treatment affects multiple survival and death pathways to promote apoptosis in mantle cell lymphoma [J].

Alinari, Lapo ;

White, Valerie L. ;

Earl, Christian T. ;

Ryan, Timothy P. ;

Johnston, Jeffrey S. ;

Dalton, James T. ;

Ferketich, Amy K. ;

Lai, Raymond ;

Lucas, David M. ;

Porcu, Pierluigi ;

Blum, Kristie A. ;

Byrd, John C. ;

Baiocchi, Robert A. .

MABS, 2009, 1 (01) :31-40

[3] Vemurafenib-resistance via de novo RBM genes mutations and chromosome 5 aberrations is overcome by combined therapy with palbociclib in thyroid carcinoma with BRAFV600E [J].

Antonello, Zeus A. ;

Hsu, Nancy ;

Bhasin, Manoj ;

Roti, Giovanni ;

Joshi, Mukta ;

Van Hummelen, Paul ;

Ye, Emily ;

Lo, Agnes S. ;

Karumanchi, S. Ananth ;

Bryke, Christine R. ;

Nucera, Carmelo .

ONCOTARGET, 2017, 8 (49) :84743-84760

[4] Structure-Activity Relationship (SAR) Study of Ethyl 2-Amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and the Potential of the Lead against Multidrug Resistance in Cancer Treatment [J].

Aridoss, Gopalakrishnan ;

Zhou, Bo ;

Hermanson, David L. ;

Bleeker, Nicholas P. ;

Xing, Chengguo .

JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (11) :5566-5581

[5] The preclinical discovery and development of bortezomib for the treatment of mantle cell lymphoma [J].

Arkwright, Richard ;

Tri Minh Pham ;

Zonder, Jeffrey A. ;

Dou, Q. Ping .

EXPERT OPINION ON DRUG DISCOVERY, 2017, 12 (02) :225-235

[6] Functional impact of NOTCH1 mutations in chronic lymphocytic leukemia [J].

Arruga, F. ;

Gizdic, B. ;

Serra, S. ;

Vaisitti, T. ;

Ciardullo, C. ;

Coscia, M. ;

Laurenti, L. ;

D'Arena, G. ;

Jaksic, O. ;

Inghirami, G. ;

Rossi, D. ;

Gaidano, G. ;

Deaglio, S. .

LEUKEMIA, 2014, 28 (05) :1060-1070

[7] Notch signaling: Cell fate control and signal integration in development [J].

Artavanis-Tsakonas, S ;

Rand, MD ;

Lake, RJ .

SCIENCE, 1999, 284 (5415) :770-776

[8] Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors [J].

Aste-Amezaga, Miguel ;

Zhang, Ningyan ;

Lineberger, Janet E. ;

Arnold, Beth A. ;

Toner, Timothy J. ;

Gu, Mingcheng ;

Huang, Lingyi ;

Vitelli, Salvatore ;

Vo, Kim T. ;

Haytko, Peter ;

Zhao, Jing Zhang ;

Baleydier, Frederic ;

L'Heureux, Sarah ;

Wang, Hongfang ;

Gordon, Wendy R. ;

Thoryk, Elizabeth ;

Andrawes, Marie Blanke ;

Tiyanont, Kittichoat ;

Stegmaier, Kimberly ;

Roti, Giovanni ;

Ross, Kenneth N. ;

Franlin, Laura L. ;

Wang, Hui ;

Wang, Fubao ;

Chastain, Michael ;

Bett, Andrew J. ;

Audoly, Laurent P. ;

Aster, Jon C. ;

Blacklow, Stephen C. ;

Huber, Hans E. .

PLOS ONE, 2010, 5 (02)

[9] Notch signaling in leukemia [J].

Aster, Jon C. ;

Pear, Warren S. ;

Blacklow, Stephen C. .

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE, 2008, 3 :587-613

[10] Targeting the Notch Pathway: Twists and Turns on the Road to Rational Therapeutics [J].

Aster, Jon C. ;

Blacklow, Stephen C. .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (19) :2418-2420

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