Lewis-Acid-Catalysed Friedel-Crafts Alkylation of Donor-Acceptor Cyclopropanes with Electron-Rich Benzenes to Generate 1,1-Diarylalkanes

被引：28
|
作者：
Kim, Areum [1 ]
Kim, Sung-Gon [1 ]
机构：
[1] Kyonggi Univ, Dept Chem, Suwon 443760, South Korea
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 2015卷 / 29期
基金：
新加坡国家研究基金会;
关键词：
Synthetic methods; Aromatic substitution; Donor-acceptor systems; Small ring systems; Cyclopropanes; Lewis acids; ASYMMETRIC-SYNTHESIS; INDOLES; 3-ALKYLINDOLES; CYCLOADDITION; DERIVATIVES; ANNULATION;
D O I：
10.1002/ejoc.201500856
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Lewis-acid-catalysed Friedel-Crafts alkylation of donor-acceptor cyclopropanes with electron-rich aromatic compounds is described. The reaction uses Yb(OTf)(3) as the catalyst, producing the desired Friedel-Crafts products with a wide range of functional groups and substitution patterns in good yield. This synthetic approach allows the construction of 1,1-diarylalkane derivatives, which are present in numerous biologically active compounds.
引用
收藏
页码：6419 / 6422
页数：4
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