N6-methyladenosine RNA modification regulates photosynthesis during photodamage in plants

被引：40

作者：

Zhang, Man ^{[1
,2
,3
,4
]}

Zeng, Yunping ^{[1
]}

Peng, Rong ^{[1
]}

Dong, Jie ^{[2
]}

Lan, Yelin ^{[2
]}

Duan, Sujuan ^{[1
]}

Chang, Zhenyi ^{[1
]}

Ren, Jian ^{[2
]}

Luo, Guanzheng ^{[2
]}

Liu, Bing ^{[2
]}

Ruzicka, Kamil ^{[5
]}

Zhao, Kewei ^{[6
]}

Wang, Hong-Bin ^{[1
,7
,8
]}

Jin, Hong-Lei ^{[1
,6
]}

机构：

[1] Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Inst Med Plant Physiol & Ecol, Guangzhou 510006, Peoples R China

[2] Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Peoples R China

[3] Guangdong Acad Agr Sci, Inst Fruit Tree Res, Guangzhou 510640, Peoples R China

[4] Guangdong Prov Key Lab Trop & Subtrop Fruit Tree, Key Lab South Subtrop Fruit Biol & Genet Resource, Guangzhou 510640, Peoples R China

[5] Czech Acad Sci, Inst Expt Bot, Lab Hormonal Regulat Plants, Prague 16502 6, Czech Republic

[6] Guangzhou Univ Chinese Med, Affiliated Hosp 3, Guangzhou Key Lab Chinese Med Res Prevent & Treat, 263 Longxi Ave, Guangzhou, Peoples R China

[7] Guangzhou Univ Chinese Med, Minist Educ, Key Lab Chinese Med Resource Lingnan, Guangzhou, Peoples R China

[8] Guangzhou Univ Chinese Med, State Key Lab Dampness Syndrome Chinese Med, Guangzhou, Peoples R China

来源：

NATURE COMMUNICATIONS | 2022年 / 13卷 / 01期

基金：

中国国家自然科学基金;

关键词：

PHOTOSYSTEM-II REPAIR; PSBA MESSENGER-RNA; GENE-EXPRESSION; HIGH-LIGHT; CHLOROPLAST-BIOGENESIS; EMBRYO DEVELOPMENT; IN-VIVO; ARABIDOPSIS; TRANSLATION; TRANSCRIPTOME;

D O I：

10.1038/s41467-022-35146-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

N-6-methyladenosine (m(6)A) modification of mRNAs affects many biological processes. However, the function of m(6)A in plant photosynthesis remains unknown. Here, we demonstrate that m(6)A modification is crucial for photosynthesis during photodamage caused by high light stress in plants. The m(6)A modification levels of numerous photosynthesis-related transcripts are changed after high light stress. We determine that the Arabidopsis m(6)A writer VIRILIZER (VIR) positively regulates photosynthesis, as its genetic inactivation drastically lowers photosynthetic activity and photosystem protein abundance under high light conditions. The m(6)A levels of numerous photosynthesis-related transcripts decrease in vir mutants, extensively reducing their transcript and translation levels, as revealed by multi-omics analyses. We demonstrate that VIR associates with the transcripts of genes encoding proteins with functions related to photoprotection (such as HHL1, MPH1, and STN8) and their regulatory proteins (such as regulators of transcript stability and translation), promoting their m(6)A modification and maintaining their stability and translation efficiency. This study thus reveals an important mechanism for m(6)A-dependent maintenance of photosynthetic efficiency in plants under high light stress conditions. Efficient photoprotection is vital for the maintenance of photosynthetic efficiency during photodamage. Here, the authors reveal that m(6)A writer VIRILIZER acts as a molecular switch of photoprotection by post-transcriptional regulation in plants.

引用

页数：19

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