Sequential Direct SNAr Reactions of Pentafluorobenzenes with Azole or Indole Derivatives

被引：33

作者：

Diness, Frederik ^{[1
]}

Begtrup, Mikael ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Drug Design & Pharmacol, DK-2100 Copenhagen, Denmark

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 11期

关键词：

ARYLATION; SUBSTITUTION; FLUORINE;

D O I：

10.1021/ol5012554

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Sequential regioselective N-arylations through high-yielding catalyst-free direct SNAr reactions of pentafluor-obenzene derivatives with azole or indole derivatives are described. The N-arylated derivatives were further functionalized through a microwave-assisted cross-coupling reaction via C-H bond activation or Suzuki conditions. The order of the reactions could be reversed, proving full orthogonality between the reactions which led to well-defined fully substituted benzene derivatives.

引用

页码：3130 / 3133

页数：4

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