Dimensions in cell migration

被引:155
作者
Doyle, Andrew D. [1 ]
Petrie, Ryan J. [1 ]
Kutys, Matthew L. [1 ]
Yamada, Kenneth M. [1 ]
机构
[1] Natl Inst Dent & Craniofacial Res, Lab Cell & Dev Biol, NIH, Bethesda, MD USA
基金
美国国家卫生研究院;
关键词
ACTIN CYTOSKELETON; MATRIX STIFFNESS; FOCAL ADHESIONS; DISTINCT ROLES; MYOSIN-IIA; INVASION; RIGIDITY; MOTILITY; MICROENVIRONMENT; DIFFERENTIATION;
D O I
10.1016/j.ceb.2013.06.004
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The importance of cell migration for both normal physiological functions and disease processes has been clear for the past 50 years. Although investigations of two-dimensional (2D) migration in regular tissue culture have elucidated many important molecular mechanisms, recent evidence suggests that cell migration depends profoundly on the dimensionality of the extracellular matrix (ECM). Here we review a number of evolving concepts revealed when cell migration is examined in different dimensions.
引用
收藏
页码:642 / 649
页数:8
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