Membranes and Sorbents

被引:19
作者
Clark, William R. [1 ]
Gao, Dayong [2 ]
Lorenzin, Anna [3 ]
Ronco, Claudio [3 ,4 ]
机构
[1] Purdue Univ, Davidson Sch Chem Engn, W Lafayette, IN 47907 USA
[2] Univ Washington, Dept Mech Engn, Seattle, WA 98195 USA
[3] San Bortolo Hosp, IRRIV, Vicenza, Italy
[4] San Bortolo Hosp, Dept Nephrol, Vicenza, Italy
来源
40 YEARS OF CONTINUOUS RENAL REPLACEMENT THERAPY | 2018年 / 194卷
关键词
POLYMYXIN-B HEMOPERFUSION; REMOVAL; SEPSIS;
D O I
10.1159/000485603
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
For continuous renal replacement therapy (CRRT), the extracorporeal filter provides solute depuration, fluid removal, and control of electrolyte and acid-base balance in critically ill patients with acute kidney injury (AKI). The membranes comprising CRRT filters are almost exclusively based on hollow fiber designs and, while adapted from the chronic hemodialysis field, have features that are specific to the requirements of CRRT nevertheless. In addition, these devices have evolved through the 40 years of CRRT in response to changes in clinical practice and the desire to extend the solute removal spectrum. For some critically ill patients, more targeted removal of specific compounds poorly cleared by standard CRRT can be attempted with techniques based on adsorption. Sorbent hemoperfusion is now being applied more broadly in critically ill patients, especially in those with sepsis and systemic inflammation. In this review, the manner in which CRRT membranes and extracorporeal sorbents have evolved over the past 40 years for the treatment of critically ill patients with AKI and other disorders is described. (c) 2018 S. Karger AG, Basel
引用
收藏
页码:70 / 79
页数:10
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