Tau Imaging in Alzheimer's Disease Diagnosis and Clinical Trials

被引：26

作者：

Brosch, Jared R. ^{[1
]}

Farlow, Martin R. ^{[1
]}

Risacher, Shannon L. ^{[2
]}

Apostolova, Liana G. ^{[1
,2
,3
]}

机构：

[1] Indiana Univ Sch Med, Dept Neurol, Indianapolis, IN 46202 USA

[2] Indiana Univ Sch Med, Dept Radiol Sci, Indianapolis, IN 46202 USA

[3] Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA

来源：

NEUROTHERAPEUTICS | 2017年 / 14卷 / 01期

关键词：

Alzheimer's disease; Tau; Tau imaging; MILD COGNITIVE IMPAIRMENT; HIPPOCAMPAL ATROPHY; PET; PATHOLOGY; BRAIN; PHOSPHORYLATION; HYPOMETABOLISM; HYPOTHESIS; DISORDERS; ISOFORMS;

D O I：

10.1007/s13311-016-0490-y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In vivo imaging of the tau protein has the potential to aid in quantitative diagnosis of Alzheimer's disease, corroborate or dispute the amyloid hypothesis, and demonstrate biomarker engagement in clinical drug trials. A host of tau positron emission tomography agents have been designed, validated, and tested in humans. Several agents have characteristics approaching the ideal imaging tracer with some limitations, primarily regarding off-target binding. Dozens of clinical trials evaluating imaging techniques and several pharmaceutical trials have begun to integrate tau imaging into their protocols.

引用

页码：62 / 68

页数：7

共 52 条

[1] 3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease [J].

Apostolova, Liana G. ;

Dinov, Ivo D. ;

Dutton, Rebecca A. ;

Hayashi, Kiralee M. ;

Toga, Arthur W. ;

Cummings, Jeffrey L. ;

Thompson, Paul M. .

BRAIN, 2006, 129 :2867-2873

[2] Conversion of mild cognitive impairment to Alzheimer disease predicted by hippocampal atrophy maps [J].

Apostolova, Liana G. ;

Dutton, Rebecca A. ;

Dinov, Ivo D. ;

Hayashi, Kiralee M. ;

Toga, Arthur W. ;

Cummings, Jeffrey L. ;

Thompson, Paul M. .

ARCHIVES OF NEUROLOGY, 2006, 63 (05) :693-699

[3] 3D Comparison of Low, Intermediate, and Advanced Hippocampal Atrophy in MCI [J].

Apostolova, Liana G. ;

Thompson, Paul M. ;

Green, Amity E. ;

Hwang, Kristy S. ;

Zoumalan, Charleen ;

Jack, Clifford R., Jr. ;

Harvey, Danielle J. ;

Petersen, Ronald C. ;

Thal, Leon J. ;

Aisen, Paul S. ;

Toga, Arthur W. ;

Cummings, Jeffrey L. ;

DeCarli, Charles S. .

HUMAN BRAIN MAPPING, 2010, 31 (05) :786-797

[4] Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal [J].

Apostolova, Liana G. ;

Mosconi, Lisa ;

Thompson, Paul M. ;

Green, Amity E. ;

Hwang, Kristy S. ;

Ramirez, Anthony ;

Mistur, Rachel ;

Tsui, Wai H. ;

de Leon, Mony J. .

NEUROBIOLOGY OF AGING, 2010, 31 (07) :1077-1088

[5] NEUROFIBRILLARY TANGLES BUT NOT SENILE PLAQUES PARALLEL DURATION AND SEVERITY OF ALZHEIMERS-DISEASE [J].

ARRIAGADA, PV ;

GROWDON, JH ;

HEDLEYWHYTE, ET ;

HYMAN, BT .

NEUROLOGY, 1992, 42 (03) :631-639

[6]

Avid Radiopharmaceuticals, 2016, 18FAV1451 AV RAD

[7] Tau-mediated neurodegeneration in Alzheimer's disease and related disorders [J].

Ballatore, Carlo ;

Lee, Virginia M. -Y. ;

Trojanowski, John Q. .

NATURE REVIEWS NEUROSCIENCE, 2007, 8 (09) :663-672

[8] NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES [J].

BRAAK, H ;

BRAAK, E .

ACTA NEUROPATHOLOGICA, 1991, 82 (04) :239-259

[9] Tau and Aβ imaging, CSF measures, and cognition in Alzheimer's disease [J].

Brier, Matthew R. ;

Gordon, Brian ;

Friedrichsen, Karl ;

McCarthy, John ;

Stern, Ari ;

Christensen, Jon ;

Owen, Christopher ;

Aldea, Patricia ;

Su, Yi ;

Hassenstab, Jason ;

Cairns, Nigel J. ;

Holtzman, David M. ;

Fagan, Anne M. ;

Morris, John C. ;

Benzinger, Tammie L. S. ;

Ances, Beau M. .

SCIENCE TRANSLATIONAL MEDICINE, 2016, 8 (338)

[10] Tau protein isoforms, phosphorylation and role in neurodegenerative disorders [J].

Buée, L ;

Bussière, T ;

Buée-Scherrer, V ;

Delacourte, A ;

Hof, PR .

BRAIN RESEARCH REVIEWS, 2000, 33 (01) :95-130

← 1 2 3 4 5 6 →