Sustainable cutaneous gene delivery

被引：70
作者：
Deng, H
Lin, Q
Khavari, PA
机构：
[1] VA PALO ALTO HLTH CARE SYST,PALO ALTO,CA 94304
[2] STANFORD UNIV,SCH MED,DEPT DERMATOL,STANFORD,CA 94305
来源：
NATURE BIOTECHNOLOGY | 1997年 / 15卷 / 13期
关键词：
gene therapy; retroviral vectors;
D O I：
10.1038/nbt1297-1388
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Durable gene delivery to human skin is necessary for lasting correction of human genetic skin disease. Current cutaneous gene-delivery strategies, however, have achieved only transient gene expression, often only within a small percentage of tissue cells. The recent inability to sustain phenotypic correction of human genetic skin disease due to loss of therapeutic gene expression in regenerated epidermal tissue has highlighted this current limitation. In an effort to surmount this problem, we have generated gene delivery vectors that produce more durable gene delivery in human skin tissue in vivo.
引用
收藏
页码：1388 / 1391
页数：4
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