Neural mediators of changes of mind about perceptual decisions

被引:97
作者
Fleming, Stephen M. [1 ,2 ]
van der Putten, Elisabeth J. [3 ]
Daw, Nathaniel D. [4 ,5 ]
机构
[1] UCL, Wellcome Ctr Human Neuroimaging, London, England
[2] UCL, Max Planck UCL Ctr Computat Psychiat & Ageing Res, London, England
[3] Univ Amsterdam, Amsterdam Brain & Cognit Ctr, Amsterdam, Netherlands
[4] Princeton Univ, Princeton Neurosci Inst, Princeton, NJ 08544 USA
[5] Princeton Univ, Dept Psychol, Princeton, NJ 08544 USA
基金
英国惠康基金;
关键词
DISCONFIRMATORY EVIDENCE; PREFRONTAL CORTEX; COGNITIVE CONTROL; BRAIN MEDIATORS; ERROR-DETECTION; FRONTAL-CORTEX; CONFIDENCE; CHOICE; TIME; METACOGNITION;
D O I
10.1038/s41593-018-0104-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Changing one's mind on the basis of new evidence is a hallmark of cognitive flexibility. To revise our confidence in a previous decision, we should use new evidence to update beliefs about choice accuracy. How this process unfolds in the human brain, however, remains unknown. Here we manipulated whether additional sensory evidence supports or negates a previous motion direction discrimination judgment while recording markers of neural activity in the human brain using fMRI. A signature of post-decision evidence (change in log-odds correct) was selectively observed in the activity of posterior medial frontal cortex. In contrast, distinct activity profiles in anterior prefrontal cortex mediated the impact of post-decision evidence on subjective confidence, independently of changes in decision value. Together our findings reveal candidate neural mediators of post-decisional changes of mind in the human brain and indicate possible targets for ameliorating deficits in cognitive flexibility.
引用
收藏
页码:617 / +
页数:12
相关论文
共 63 条
[41]   Connectivity reveals relationship of brain areas for reward-guided learning and decision making in human and monkey frontal cortex [J].
Neubert, Franz-Xaver ;
Mars, Rogier B. ;
Sallet, Jerome ;
Rushworth, Matthew F. S. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (20) :E2695-E2704
[42]   Comparison of Human Ventral Frontal Cortex Areas for Cognitive Control and Language with Areas in Monkey Frontal Cortex [J].
Neubert, Franz-Xaver ;
Mars, Rogier B. ;
Thomas, Adam G. ;
Sallet, Jerome ;
Rushworth, Matthew F. S. .
NEURON, 2014, 81 (03) :700-713
[43]   The VideoToolbox software for visual psychophysics: Transforming numbers into movies [J].
Pelli, DG .
SPATIAL VISION, 1997, 10 (04) :437-442
[44]   Two-Stage Dynamic Signal Detection: A Theory of Choice, Decision Time, and Confidence [J].
Pleskac, Timothy J. ;
Busemeyer, Jerome R. .
PSYCHOLOGICAL REVIEW, 2010, 117 (03) :864-901
[45]   Confidence and certainty: distinct probabilistic quantities for different goals [J].
Pouget, Alexandre ;
Drugowitsch, Jan ;
Kepecs, Adam .
NATURE NEUROSCIENCE, 2016, 19 (03) :366-374
[46]   Hierarchical decision processes that operate over distinct timescales underlie choice and changes in strategy [J].
Purcell, Braden A. ;
Kiani, Roozbeh .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (31) :E4531-E4540
[47]   Changes of mind in decision-making [J].
Resulaj, Arbora ;
Kiani, Roozbeh ;
Wolpert, Daniel M. ;
Shadlen, Michael N. .
NATURE, 2009, 461 (7261) :263-U141
[48]  
Roitman JD, 2002, J NEUROSCI, V22, P9475
[49]   Choice, uncertainty and value in prefrontal and cingulate cortex [J].
Rushworth, Matthew F. S. ;
Behrens, Timothy E. J. .
NATURE NEUROSCIENCE, 2008, 11 (04) :389-397
[50]   Signatures of a Statistical Computation in the Human Sense of Confidence [J].
Sanders, Joshua I. ;
Hangya, Balazs ;
Kepecs, Adam .
NEURON, 2016, 90 (03) :499-506