Host-guest interaction between pinocembrin and cyclodextrins: Characterization, solubilization and stability

被引：32
|
作者：
Zhou, Shu-Ya [1 ,2 ]
Ma, Shui-Xian [1 ,2 ]
Cheng, Hui-Lin [4 ]
Yang, Li-Juan [1 ,2 ]
Chen, Wen [3 ]
Yin, Yan-Qing [1 ,2 ]
Shi, Yi-Min [1 ,2 ]
Yang, Xiao-Dong [3 ]
机构：
[1] Yunnan Univ Nationalities, Key Lab Ethn Med Resource Chem, State Ethn Affairs Commiss, Kunming 650500, Peoples R China
[2] Yunnan Univ Nationalities, Minist Educ, Kunming 650500, Peoples R China
[3] Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ, Kunming 650091, Peoples R China
[4] Kunming Univ Sci & Technol, Coll Sci, Kunming 650500, Peoples R China
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2014年 / 1058卷
关键词：
Pinocembrin; Cyclodextrin; Inclusion complexes; Solubilization; Stability; BETA-CYCLODEXTRIN; BRIDGED BIS(BETA-CYCLODEXTRIN)S; INCLUSION COMPLEXES; PROTECTS; EXTRACT; BINDING; SYSTEM; MODE; DRUG;
D O I：
10.1016/j.molstruc.2013.11.008
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The inclusion complexation behavior, characterization and binding ability of pinocembrin with p-cyclodextrin (beta-CD) and its derivative 2-hydroxypropyl-beta-cyclodextrin (HP beta CD) were investigated in both solution and the solid state by means of XRD, DSC, H-1 and 2D NMR and UV-vis spectroscopy. The results showed that the water solubility and thermal stability of pinocembrin were obviously increased in the inclusion complex with cyclodextrins. This satisfactory water solubility and high stability of the pinocembrin/CD complexes will be potentially useful for their application as herbal medicines or healthcare products. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：181 / 188
页数：8
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