Understanding Cone Photoreceptor Cell Death in Achromatopsia

被引：4

作者：

Carvalho, Livia S. ^{[1
]}

Vandenberghe, Luk H. ^{[1
]}

机构：

[1] Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Dept Ophthalmol,Ocular Genom Inst,Schepens Eye Re, 20 Staniford St, Boston, MA 02114 USA

来源：

RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY | 2016年 / 854卷

关键词：

Achromatopsia; Cone dystrophies; Cone photoreceptors; Cell death; Cone degeneration; Apoptosis; CNG CHANNELS; MICE LACKING; DEGENERATION; MUTATIONS; MUTANT;

D O I：

10.1007/978-3-319-17121-0_31

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Colour vision is only achieved in the presence of healthy and functional cone photoreceptors found in the retina. It is an essential component of human vision and usually the first complaint patients undergoing vision degeneration have is the loss of daylight colour vision. Therefore, an understanding of the biology and basic mechanisms behind cone death under the degenerative state of retinal dystrophies and how the activation of the apoptotic pathway is triggered will provide valuable knowledge. It will also have broader applications for a spectrum of visual disorders and will be critical for future advances in translational research.

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页码：231 / 236

页数：6

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