On a Path to Unfolding the Biological Mechanisms of Orthodontic Tooth Movement

被引:240
作者
Krishnan, V. [1 ]
Davidovitch, Z. [1 ]
机构
[1] Case Western Reserve Univ, Dept Orthodont, Cleveland, OH 44106 USA
关键词
tooth movement; cellular mechanotransduction; extracellular matrix; cytoskeleton; nucleic acids; osteocytes; fibroblasts; angiogenesis; mechanoreceptors; PERIODONTAL-LIGAMENT CELLS; GINGIVAL CREVICULAR FLUID; FIBROBLASTS IN-VITRO; EXTRACELLULAR-MATRIX; SUBSTANCE-P; FORCE APPLICATION; GENE-EXPRESSION; BONE-RESORPTION; SHEAR STRESSES; OSTEOCYTES;
D O I
10.1177/0022034509338914
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Orthodontic forces deform the extracellular matrix and activate cells of the paradental tissues, facilitating tooth movement. Discoveries in mechanobiology have illuminated sequential cellular and molecular events, such as signal generation and transduction, cytoskeletal reorganization, gene expression, differentiation, proliferation, synthesis and secretion of specific products, and apoptosis. Orthodontists work in a unique biological environment, wherein applied forces engender remodeling of both mineralized and nonmineralized paradental tissues, including the associated blood vessels and neural elements. This review aims at identifying events that affect the sequence, timing, and significance of factors that determine the nature of the biological response of each paradental tissue to orthodontic force. The results of this literature review emphasize the fact that mechanoresponses and inflammation are both essential for achieving tooth movement clinically. If both are working in concert, orthodontists might be able to accelerate or decelerate tooth movement by adding adjuvant methods, whether physical, chemical, or surgical.
引用
收藏
页码:597 / 608
页数:12
相关论文
共 50 条
[41]   Osteoprotegerin and zoledronate bone effects during orthodontic tooth movement [J].
Fernandez-Gonzalez, F. J. ;
Lopez-Caballo, J. L. ;
Canigral, A. ;
Menendez-Diaz, I. ;
Brizuela, A. ;
de Cos, F. J. ;
Cobo, T. ;
Vega, J. A. .
ORTHODONTICS & CRANIOFACIAL RESEARCH, 2016, 19 (01) :54-64
[42]   Development of a three-dimensional in vitro model system to study orthodontic tooth movement [J].
Heckler, A. F. ;
Mirzaer, Z. ;
Pereira, I. ;
Simmons, C. A. ;
Gong, S. -G. .
ARCHIVES OF ORAL BIOLOGY, 2013, 58 (10) :1498-1510
[43]   Orthodontic tooth movement following analgesic treatment with Aspirin and Algocalmin. An experimental study [J].
Olteanu, Cristian Doru ;
Serbanescu, Alin ;
Bosca, Adina Bianca ;
Mihu, Carmen Mihaela .
ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY, 2015, 56 (04) :1339-1344
[44]   MMPs and TIMPs Expression Levels in the Periodontal Ligament during Orthodontic Tooth Movement: A Systematic Review of In Vitro and In Vivo Studies [J].
Behm, Christian ;
Nemec, Michael ;
Weissinger, Fabian ;
Rausch, Marco Aoqi ;
Andrukhov, Oleh ;
Jonke, Erwin .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (13)
[45]   The effect of caffeine on orthodontic tooth movement in rats [J].
Shirazi, Mohsen ;
Vaziri, Hamed ;
Salari, Behzad ;
Motahhari, Pouria ;
Etemad-Moghadam, Shahroo ;
Dehpour, Ahmad Reza .
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2017, 20 (03) :260-264
[46]   Influence of bisphosphonates on orthodontic tooth movement in mice [J].
Fujimura, Yuji ;
Kitaura, Hideki ;
Yoshimatsu, Masako ;
Eguchi, Toshiko ;
Kohara, Haruka ;
Morita, Yukiko ;
Yoshida, Noriaki .
EUROPEAN JOURNAL OF ORTHODONTICS, 2009, 31 (06) :572-577
[47]   Orthodontic tooth movement: The biology and clinical implications [J].
Li, Yina ;
Jacox, Laura A. ;
Little, Shannyn H. ;
Ko, Ching-Chang .
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES, 2018, 34 (04) :207-214
[48]   Effects of icariin on orthodontic tooth movement in rats [J].
Chen, Yun ;
Wang, Xu-Xia ;
Zhao, Bing-Jie ;
Bu, Jie ;
Su, Yu-Ran ;
Zhang, Jun .
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2015, 8 (06) :8608-8616
[49]   Orthodontic tooth movement and HMGB1 [J].
Kanzaki, Hiroyuki ;
Nakamura, Yoshiki .
JOURNAL OF ORAL BIOSCIENCES, 2018, 60 (02) :49-53
[50]   Clear aligners generations and orthodontic tooth movement [J].
Hennessy, Joe ;
Al-Awadhi, Ebrahim A. .
JOURNAL OF ORTHODONTICS, 2016, 43 (01) :68-76