Ruthenium(II)-Catalyzed Regioselective-Controlled Allenylation/Cyclization of Benzimides with Propargyl Alcohols

被引：42

作者：

Anukumar, Adapa ^{[1
]}

Tamizmani, Masilamani ^{[1
]}

Jeganmohan, Masilamani ^{[1
]}

机构：

[1] Indian Inst Technol Madras, Dept Chem, Madras 600036, Tamil Nadu, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 15期

关键词：

H BOND ACTIVATION; OXIDATIVE CYCLIZATION; C-C; ALKYNES; ALKENES; BENZAMIDES; ARYLATION; NITRILES; FUNCTIONALIZATION; 1H-INDAZOLES;

D O I：

10.1021/acs.joc.8b01123

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A ruthenium(II)-catalyzed cyclization of benzimidates with substituted propargyl alcohols to provide 3,4-disubstituted 1-alkoxy isoquinolines in a highly selective manner via the C-H allenylation is described. The proposed reaction mechanism of the ruthenium(II)-catalyzed cyclization reaction is strongly supported by the isolation of the key ruthenacycle intermediate, deuterium-labeling studies, and detailed DFT calculations including the transition states.

引用

页码：8567 / 8580

页数：14

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