Multifunctional ionic liquid-bound polystyrene resin with high loading capacity as support in solid-phase peptide synthesis

被引：6
|
作者：
Patra, Tanmoy [1 ]
Karmakar, Sandip [2 ]
Upadhyayula, Sreedevi [1 ]
机构：
[1] Indian Inst Technol Delhi, Dept Chem Engn, New Delhi 110016, India
[2] Indian Inst Technol Delhi, Dept Chem, New Delhi 110016, India
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 15期
关键词：
Ionic liquid; Peptide synthesis; Peptides; SPPS; Amino acid; PROTECTING GROUP;
D O I：
10.1016/j.tetlet.2017.03.014
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Polystyrene resin-bound ionic liquids (PSILs) with high loading capacities were prepared by immobilizing multifunctional ionic liquids (ILs) on modified polystyrene (PS) resin and used in the solid phase peptide synthesis. Introduction of hydrophobic anions and functional side chain containing ILs resulted in high yield (82-98%) and purity (92-98%) of the synthesized peptides. The coupling kinetic studies of the first and second amino acids to the PSILs were performed to investigate the effect of IL functionalization on PS supports. (C) 2017 Elsevier Ltd. All rights reserved.
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收藏
页码：1531 / 1534
页数：4
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