Nitric Oxide and Hydrogen Sulfide: A Nice Pair in the Respiratory System

被引：10

作者：

Fuschillo, Salvatore ^{[1
]}

Palomba, Letizia ^{[2
]}

Capparelli, Rosanna ^{[3
]}

Motta, Andrea ^{[4
]}

Maniscalco, Mauro ^{[1
]}

机构：

[1] Ist Clin Sci Maugeri IRCCS, Telese Terme Inst, Pulm Rehabil Div, I-82037 Telese Terme, BN, Italy

[2] Univ Urbino Carlo Bo, Dept Biomol Sci, I-61029 Urbino, PU, Italy

[3] Univ Naples Federico II, Dept Agr, I-80055 Portici, NA, Italy

[4] CNR, Inst Biomol Chem, I-80078 Pozzuoli, NA, Italy

来源：

CURRENT MEDICINAL CHEMISTRY | 2020年 / 27卷 / 42期

关键词：

Nitric oxide; H2S; biomarkers; disability; outcome; pathological process; PULMONARY-HYPERTENSION; OXIDATIVE STRESS; S-NITROSOTHIOL; LUNG INJURY; SYNTHASE; H2S; INFLAMMATION; RELAXATION; PATHOPHYSIOLOGY; BRONCHODILATOR;

D O I：

10.2174/0929867327666200310120550

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitric Oxide (NO) is internationally regarded as a signal molecule involved in several functions in the respiratory tract under physiological and pathogenic conditions. Hydrogen Sulfide (H2S) has also recently been recognized as a new gasotransmitter with a diverse range of functions similar to those of NO. Depending on their respective concentrations, both these molecules act synergistically or antagonistically as signals or damage promoters. Nevertheless, available evidence shows that the complex biological connections between NO and H2S involve multiple pathways and depend on the site of action in the respiratory tract, as well as on experimental conditions. This review will provide an update on these two gasotransmitters in physiological and pathological processes.

引用

页码：7136 / 7148

页数：13

共 102 条

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