Antidiabetogenic Constituents from the Thai Traditional Medicine Cotylelobium melanoxylon

被引：40

作者：

Matsuda, Hisashi ^{[1
]}

Asao, Yasunobu ^{[1
]}

Nakamura, Seikou ^{[1
]}

Hamao, Makoto ^{[1
]}

Sugimoto, Sachiko ^{[1
]}

Hongo, Masako ^{[1
]}

Pongpiriyadacha, Yutana ^{[2
]}

Yoshikawa, Masayuki ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan

[2] Univ Technol Srivijaya, Fac Sci & Technol, Thungyai 80240, Nakhonsithammar, Thailand

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2009年 / 57卷 / 05期

关键词：

Cotylelobium melanoxylon; melanoxylin A; melanoxylin B; stilbene oligomer; plasma glucose elevation inhibitor; plasma triglyceride elevation inhibitor; CHINESE NATURAL MEDICINES; BREVIPEDUNCULATA VAR HANCEI; BIOACTIVE CONSTITUENTS; VATICA-RASSAK; SUPEROXIDE-PRODUCTION; BOESENBERGIA-ROTUNDA; ALDOSE REDUCTASE; ERYCIBE-EXPANSA; STEM BARK; A-C;

D O I：

10.1248/cpb.57.487

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The methanolic extracts from the wood and bark of Cotylelobium melanoxylon were found to inhibit plasma glucose elevation after sucrose loading in rats and triglyceride elevation after olive oil loading in mice. A new stilbene dimer, melanoxylin A, together with the known stilbene dimers [(+)-ampelopsin F, (+)-isoampelopsin F, and (+)-epsilon-viniferin] and a trimer (vaticanol G) and a lignan [(+)-lyoniresinol] were isolated from the wood extract, and a new stilbene trimer, melanoxylin B, together with the known stilbene dimers [(+)-epsilon-viniferin and cis-(+)-epsilon-viniferin] and trimers (vaticanols A, E, and G) were isolated from the bark extract of C. melanoxylon. The principal constituents, vaticanols A, E, and/or G, inhibited plasma glucose and triglyceride elevation after sucrose loading in rats and olive oil loading in mice, respectively. In addition, vaticanols A, E, and/or G inhibited the enzyme activities of rat intestinal alpha-glucosidase, porcine pancreatic lipase, and rat lens aldose reductase.

引用

页码：487 / 494

页数：8

共 39 条

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