Adjuvant treatment of colorectal cancer (current expert opinion derived from the Third International Conference: Perspectives in Colorectal Cancer, Dublin, 2001)

被引:48
作者
Van Cutsem, E
Dicato, M
Wils, J
Cunningham, D
Diaz-Rubio, E
Glimelius, B
Haller, D
Johnston, P
Kerr, D
Koehne, CH
Labianca, R
Minsky, B
Nordlinger, B
Roth, A
Rougier, P
Schmoll, HJ
机构
[1] Univ Hosp Gasthuisberg, Dept Internal Med, B-3000 Louvain, Belgium
[2] Ctr Hosp Luxembourg, Luxembourg, Luxembourg
[3] St Laurentius Hosp, Roermond, Netherlands
[4] Royal Marsden Hosp, London SW3 6JJ, England
[5] Univ Madrid, Hosp San Carlos, Madrid 3, Spain
[6] Akad Sjukhuset, Uppsala, Sweden
[7] Univ Penn, Ctr Canc, Philadelphia, PA 19104 USA
[8] Queens Univ Belfast, Belfast, Antrim, North Ireland
[9] Univ Oxford, Oxford, England
[10] Univ Clin Dresden, Dresden, Germany
[11] Osped Riuniti Bergamo, I-24100 Bergamo, Italy
[12] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
[13] CHU Ambroise Pare, Boulogne, France
[14] Hop Univ Geneve, Geneva, Switzerland
[15] Univ Halle Wittenberg, Halle An Der Saale, Germany
关键词
colon cancer; rectal cancer; adjuvant chemotherapy; adjuvant radiotherapy;
D O I
10.1016/S0959-8049(02)00122-3
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
This article summarises the progress that has been made in the adjuvant treatment of colorectal cancer over the last decade. In view of the consequent improvements in recurrence rates and in overall survival, the development of effective adjuvant treatments for colorectal cancer is considered as one of the most important to be made in clinical oncology over the last decade. Treatment recommendations based on evidence-based data and on expert opinions are summarised in this manuscript. However, a consensus cannot be reached on all aspects of treatment because of data that is currently emerging that will influence clinical practice and because of the many ongoing clinical trials. Those involved in the treatment of colorectal cancer should therefore be encouraged to continue to provide optimal patient care and to participate in well designed clinical trials in order to increase the evidence upon which they can base their clinical judgements and in order to make further progress. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1429 / 1436
页数:8
相关论文
共 47 条
[1]  
[Anonymous], 1985, NEW ENGL J MED, V312, P1465
[2]  
[Anonymous], P AM SOC CLIN ONCOLO
[3]  
Bosset JF, 2000, SEMIN ONCOL, V27, P60
[4]   Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: A French intergroup study [J].
deGramont, A ;
Basset, JF ;
Milan, C ;
Rougier, P ;
Bouche, O ;
Etienne, PL ;
Morvan, F ;
Louvet, C ;
Guillot, C ;
Francois, E ;
Bedenne, L .
JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (02) :808-815
[5]  
DOUGLASS HO, 1986, NEW ENGL J MED, V315, P1294
[6]   Efficacy of adjuvant fluorouracil and folinic acid in B2 colon cancer [J].
Erlichman, C ;
O'Connell, M ;
Kahn, M ;
Marsoni, S ;
Torri, V ;
Tardio, B ;
Zaniboni, A ;
Pancera, G ;
Martignoni, G ;
Labianca, R ;
Barni, A ;
Seitz, JF ;
Milan, C ;
Bedenne, L ;
Giovannini, M ;
Letreut, YP ;
Skillings, J ;
Shepard, L ;
Zee, B ;
Petrioli, R ;
Francini, G .
JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (05) :1356-1363
[7]   POSTOPERATIVE ADJUVANT CHEMOTHERAPY OR RADIATION-THERAPY FOR RECTAL-CANCER - RESULTS FROM NSABP PROTOCOL R-01 [J].
FISHER, B ;
WOLMARK, N ;
ROCKETTE, H ;
REDMOND, C ;
DEUTSCH, M ;
WICKERHAM, DL ;
FISHER, ER ;
CAPLAN, R ;
JONES, J ;
LERNER, H ;
GORDON, P ;
FELDMAN, M ;
CRUZ, A ;
LEGAULTPOISSON, S ;
WEXLER, M ;
LAWRENCE, W ;
ROBIDOUX, A .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1988, 80 (01) :21-29
[8]   FOLINIC ACID AND 5-FLUOROURACIL AS ADJUVANT CHEMOTHERAPY IN COLON-CANCER [J].
FRANCINI, G ;
PETRIOLI, R ;
LORENZINI, L ;
MANCINI, S ;
ARMENIO, S ;
TANZINI, G ;
MARSILI, S ;
AQUINOA ;
MARZOCCA, G ;
CIVITELLI, S ;
MARIANI, L ;
DESANDO, D ;
BOVENGA, S ;
LORENZI, M .
GASTROENTEROLOGY, 1994, 106 (04) :899-906
[9]   Chemoradiotherapy for rectal cancer - is there an optimal combination? [J].
Glimelius, B .
ANNALS OF ONCOLOGY, 2001, 12 (08) :1039-1045
[10]  
Gray R, 1997, JNCI-J NATL CANCER I, V89, P497