Palladium- Catalyzed Intermolecular C-2 Alkenylation of Indoles Using Oxygen as the Oxidant

被引：44

作者：

Yan, Zhao-Lei ^{[1
]}

Chen, Wen-Liang ^{[1
]}

Gao, Ya-Ru ^{[1
]}

Mao, Shuai ^{[1
]}

Zhang, Yan-Lei ^{[1
]}

Wang, Yong-Qiang ^{[1
]}

机构：

[1] NW Univ Xian, Minist Educ, Dept Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Xian 710069, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2014年 / 356卷 / 05期

基金：

中国国家自然科学基金;

关键词：

C-2; alkenylation; CH activation; indoles; oxygen oxidation; palladium-catalyzed reaction; H BOND FUNCTIONALIZATION; BIOLOGICAL EVALUATION; OLEFINATION; C2-ALKENYLATION; ALKALOIDS; HETEROCYCLES; ARENES; MILD;

D O I：

10.1002/adsc.201300811

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A general and efficient palladium-catalyzed intermolecular direct C-2 alkenylation of indoles using oxygen as the oxidant has been developed. The reaction is of complete regio- and stereoselectivity. All products are E-isomers at the C-2-position with no Z-isomers and 3-substituted products were detected.

引用

页码：1085 / 1092

页数：8

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