Pharmacology of serotonin and female sexual behavior

被引：30
作者：
Uphouse, Lynda [1 ]
机构：
[1] Texas Womans Univ, Dept Biol, Denton, TX 76204 USA
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2014年 / 121卷
关键词：
Review; Sexual receptivity; Proceptivity; SSRIs; Sexual motivation; 5-HT receptors; 5-HT1A RECEPTOR AGONIST; PREMENOPAUSAL WOMEN EFFICACY; MEDIAL PREOPTIC AREA; LORDOSIS BEHAVIOR; DESIRE DISORDER; RAT HIPPOCAMPUS; RAPHE NUCLEI; REUPTAKE INHIBITORS; MILD RESTRAINT; IN-VITRO;
D O I：
10.1016/j.pbb.2013.11.008
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
In this review, first a historical perspective of serotonin's (5-HT) involvement in female sexual behavior is presented. Then an overview of studies implicating 5-HT is presented. The effect of drugs that increase or decrease CNS levels of 5-HT is reviewed. Evidence is presented that drugs which increase 5-HT have negative effects on female sexual behavior while a decrease in 5-HT is associated with facilitation of sexual behavior. Studies with compounds that act on 5-HT1, 5-HT2 or 5-HT3 receptors are discussed. Most evidence indicates that 5-HT1A receptor agonists inhibit sexual behavior while 5-HT2 or 5-HT3 receptors may exert a positive influence. There is substantial evidence to support a role for 5-HT in the modulation of female consummatory sexual behavior, but studies on the role of 5-HT in other elements of female sexual behavior (e.g. desire, motivation, sexual appetite) are few. Future studies should be directed at determining if these additional components of female sexual behavior are also modulated by 5-HT. (C) 2013 Elsevier Inc. All rights reserved.
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收藏
页码：31 / 42
页数：12
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