Chronotherapy of cancer: periodic perturbations in vascular growth and metastasis

被引:3
作者
Jaime, J. C. [1 ]
Mesa-Alvarez, M. D. [1 ]
Martin, R. R. [1 ]
Betancourt-Mar, J. A. [2 ]
Cocho, G. [3 ]
Mansilla, R. [4 ]
Nieto-Villar, J. M. [1 ]
机构
[1] Univ Havana, Fac Chem, A Alzola Grp Thermodynam Complex Syst MV Lomonoso, Dept Chem Phys, Havana, Cuba
[2] Mexican Inst Complex Syst, Tampico, Tamaulipas, Mexico
[3] Univ Nacl Autonoma Mexico, Inst Fis, Mexico City, DF, Mexico
[4] Univ Nacl Autonoma Mexico, Ctr Invest Interdisciplinarias Ciencias & Humanid, Mexico City, DF, Mexico
关键词
Vascular growth; metastasis; chronotherapy; complex systems; IMMUNOTHERAPY;
D O I
10.1080/09291016.2018.1465698
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A non-autonomous model was developed for vascular tumor growth and cancer metastasis under periodic perturbations that simulate chronotherapy. It was found that for a critical amplitude and a perturbation frequency of twice the autonomous frequency in vascular growth, less complex and therefore less robust states are reached and the tumor population decreases. In metastasis, similar results were found for a perturbation frequency equal to the autonomous frequency. In metastasis, similar behaviors occur, for a perturbation's frequency equal to the fundamental frequency of system.
引用
收藏
页码:495 / 504
页数:10
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