(-) - Riboflavin (vitamin B2) and flavin mononucleotide as visible light photo initiators in the thiol-ene polymerisation of PEG-based hydrogels

被引：55
作者：
Batchelor, R. R. [1 ,2 ]
Kwandou, G. [1 ]
Spicer, P. T. [1 ]
Stenzel, M. H. [2 ,3 ]
机构：
[1] Univ New South Wales, Sch Chem Engn, Sydney, NSW 2052, Australia
[2] Univ New South Wales, CAMD, Sydney, NSW 2052, Australia
[3] Univ New South Wales, Sch Chem, Sydney, NSW 2052, Australia
来源：
POLYMER CHEMISTRY | 2017年 / 8卷 / 06期
关键词：
CLICK CHEMISTRY; PHOTOPOLYMERIZATION; PHOTOINITIATOR; MONOMERS; DELIVERY; BLUE;
D O I：
10.1039/c6py02034h
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The photoinitiators used in light mediated hydrogelation have been limited due to cytotoxicity and solubility issues. Here we report the use of riboflavin and flavin mononucleotide as nontoxic, naturally occurring photoinitiators for the thiol-ene hydrogelation of functionalised poly(ethylene glycol). High Resolution Magic Angle Spinning (HRMAS) NMR spectroscopy and oscillatory rheometry were used to probe the efficiency of these initiators for this hydrogel system. The gelation and reaction progression could easily be manipulated using different initiator concentrations and light intensities.
引用
收藏
页码：980 / 984
页数：5
相关论文
共 29 条
  • [1] Poly(ethylene glycol) hydrogels formed by thiol-ene photopolymerization for enzyme-responsive protein delivery
    Aimetti, Alex A.
    Machen, Alexandra J.
    Anseth, Kristi S.
    [J]. BIOMATERIALS, 2009, 30 (30) : 6048 - 6054
  • [2] Synthetically Tractable Click Hydrogels for Three-Dimensional Cell Culture Formed Using Tetrazine-Norbornene Chemistry
    Alge, Daniel L.
    Azagarsamy, Malar A.
    Donohue, Dillon F.
    Anseth, Kristi S.
    [J]. BIOMACROMOLECULES, 2013, 14 (04) : 949 - 953
  • [3] The performance of human mesenchymal stem cells encapsulated in cell-degradable polymer-peptide hydrogels
    Anderson, Sarah B.
    Lin, Chien-Chi
    Kuntzler, Donna V.
    Anseth, Kristi S.
    [J]. BIOMATERIALS, 2011, 32 (14) : 3564 - 3574
  • [4] KINETIC EVIDENCE OF REACTION-DIFFUSION DURING THE POLYMERIZATION OF MULTI(METH)ACRYLATE MONOMERS
    ANSETH, KS
    WANG, CM
    BOWMAN, CN
    [J]. MACROMOLECULES, 1994, 27 (03) : 650 - 655
  • [5] Photocrosslinking of Silk Fibroin Using Riboflavin for Ocular Prostheses
    Applegate, Matthew B.
    Partlow, Benjamin P.
    Coburn, Jeannine
    Marelli, Benedetto
    Pirie, Christopher
    Pineda, Roberto
    Kaplan, David L.
    Omenetto, Fiorenzo G.
    [J]. ADVANCED MATERIALS, 2016, 28 (12) : 2417 - 2420
  • [6] Characterization of valvular interstitial cell function in three dimensional matrix metalloproteinase degradable PEG hydrogels
    Benton, Julie A.
    Fairbanks, Benjamin D.
    Anseth, Kristi S.
    [J]. BIOMATERIALS, 2009, 30 (34) : 6593 - 6603
  • [7] Riboflavin triethanolamine as photoinitiator system of vinyl polymerization. A mechanistic study by laser flash photolysis
    Bertolotti, SG
    Previtali, CM
    Rufs, AM
    Encinas, MV
    [J]. MACROMOLECULES, 1999, 32 (09) : 2920 - 2924
  • [8] Toward an Enhanced Understanding and Implementation of Photopolymerization Reactions
    Bowman, Christopher N.
    Kloxin, Christopher J.
    [J]. AICHE JOURNAL, 2008, 54 (11) : 2775 - 2795
  • [9] Encapsulating Chondrocytes in degrading PEG hydrogels with high modulus: Engineering gel structural changes to facilitate cartilaginous tissue production
    Bryant, SJ
    Bender, RJ
    Durand, KL
    Anseth, KS
    [J]. BIOTECHNOLOGY AND BIOENGINEERING, 2004, 86 (07) : 747 - 755
  • [10] CAIRNS WL, 1971, J AM CHEM SOC, V93, P2772
123