C-H Functionalization at Sterically Congested Positions by the Platinum-Catalyzed Borylation of Arenes

被引：98

作者：

Furukawa, Takayuki ^{[1
]}

Tobisu, Mamoru ^{[2
,3
]}

Chatani, Naoto ^{[1
]}

机构：

[1] Osaka Univ, Fac Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Engn, Ctr Atom & Mol Technol, Suita, Osaka 5650871, Japan

[3] Kyoto Univ, ESICB, Kyoto 6158510, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 38期

关键词：

N-HETEROCYCLIC CARBENE; ARYL; COMPLEXES; BONDS; CONSTRUCTION; ACTIVATION; PALLADIUM; CHEMISTRY; MECHANISM; CLEAVAGE;

D O I：

10.1021/jacs.5b07677

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Despite significant progress in the area of C-H bond functionalization of arenes, no general method has been reported for the functionalization of C-H bonds at the sterically encumbered positions of simple arenes, such as mesitylene. Herein, we report the development of the first platinum-based catalyst for C-H borylation of arenes and heteroarenes. Notably, this method exhibited high tolerance toward steric hindrance and provided rapid access to a series of 2,6-disubstituted phenylboronic esters, valuable building blocks for further elaborations.

引用

页码：12211 / 12214

页数：4

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