Pack size and paracetamol overdose: 16 years later

被引:13
作者
Bateman, D. Nicholas [1 ]
机构
[1] Univ Edinburgh, Edinburgh EH16 4TJ, Midlothian, Scotland
关键词
Paracetamol; Analgesics; Pharmaceuticals; Pack size; Drug regulation; ACETAMINOPHEN; UK;
D O I
10.3109/15563650.2014.952432
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
In 1998 the United Kingdom limited the availability of paracetamol sold over-the-counter in an effort to reduce serious paracetamol overdose. Since that time debate has continued on the effectiveness of this policy in reducing what is acknowledged as a major public health problem. This commentary reviews recent publications on this topic which suggest that the effects were small. Reasons for this are discussed using data from recent work.
引用
收藏
页码:821 / 823
页数:3
相关论文
共 14 条
[1]   Effect of the UK's revised paracetamol poisoning management guidelines on admissions, adverse reactions and costs of treatment [J].
Bateman, D. Nicholas ;
Carroll, Robert ;
Pettie, Janice ;
Yamamoto, Takahiro ;
Elamin, Muhammad E. M. O. ;
Peart, Lucy ;
Dow, Margaret ;
Coyle, Judy ;
Cranfield, Kristina R. ;
Hook, Christopher ;
Sandilands, Euan A. ;
Veiraiah, Aravindan ;
Webb, David ;
Gray, Alasdair ;
Dargan, Paul I. ;
Wood, David M. ;
Thomas, Simon H. L. ;
Dear, James W. ;
Eddleston, Michael .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2014, 78 (03) :610-618
[2]   Limiting paracetamol pack size: has it worked in the UK? [J].
Bateman, D. Nicholas .
CLINICAL TOXICOLOGY, 2009, 47 (06) :536-541
[3]   Does restricting pack size of paracetamol (acetaminophen) reduce suicides? [J].
Buckley, Nicholas A. ;
Gunnell, David .
PLOS MEDICINE, 2007, 4 (04) :612-613
[4]  
FDA, 2009, JOINT M DRUG SAF RIS
[5]   Paracetamol availability and recent changes in paracetamol poisoning: is the 1998 legislation limiting availability of paracetamol being followed? [J].
Greene, S. L. ;
Dargan, P. I. ;
Leman, P. ;
Jones, A. L. .
POSTGRADUATE MEDICAL JOURNAL, 2006, 82 (970) :520-523
[6]   Drugs and other chemicals involved in fatal poisoning in England and Wales during 2000-2011 [J].
Handley, S. A. ;
Flanagan, R. J. .
CLINICAL TOXICOLOGY, 2014, 52 (01) :1-12
[7]   Long term effect of reduced pack sizes of paracetamol on poisoning deaths and liver transplant activity in England and Wales: interrupted time series analyses [J].
Hawton, Keith ;
Bergen, Helen ;
Simkin, Sue ;
Dodd, Sue ;
Pocock, Phil ;
Bernal, William ;
Gunnell, David ;
Kapur, Navneet .
BMJ-BRITISH MEDICAL JOURNAL, 2013, 346
[8]   Impact of different pack sizes of paracetamol in the United Kingdom and Ireland on intentional overdoses: a comparative study [J].
Hawton, Keith ;
Bergen, Helen ;
Simkin, Sue ;
Arensman, Ella ;
Corcoran, Paul ;
Cooper, Jayne ;
Waters, Keith ;
Gunnell, David ;
Kapur, Navneet .
BMC PUBLIC HEALTH, 2011, 11
[10]   Interrupted time-series analysis of regulations to reduce paracetamol (acetaminophen) poisoning [J].
Morgan, Oliver W. ;
Griffiths, Clare ;
Majeed, Azeem .
PLOS MEDICINE, 2007, 4 (04) :654-659