SLIT's Prevention of the Allergic March

被引：11
作者：
Porcaro, Federica [1 ]
Corsello, Giovanni [2 ]
Pajno, Giovanni Battista [3 ]
机构：
[1] Bambino Gesu Pediat Hosp, Acad Dept Pediat, Sleep & Long Tenn Ventilat Unit, Resp Unit,Pediat Pulmonol & Resp Intermediate Car, Piazza S Onofrio 4, I-00165 Rome, Italy
[2] Univ Palermo, Dept Sci Hlth Promot & Mother & Child Care G DAle, AOUP R Giaccone, Neonatal Intens Care Unit, Via Alfonso Giordano 3, I-90127 Palemio, Italy
[3] Univ Messina, Dept Pediat, Allergy Unit, Messina, Italy
来源：
CURRENT ALLERGY AND ASTHMA REPORTS | 2018年 / 18卷 / 05期
关键词：
Allergic march; Allergen immunotherapy; Sublingual immunotherapy; Primary prevention; Secondary prevention; HOUSE-DUST MITE; RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIAL; SUBLINGUAL IMMUNOTHERAPY; ATOPIC-DERMATITIS; FOLLOW-UP; LONG-TERM; FILAGGRIN MUTATIONS; DOUBLE-BLIND; EOSINOPHILIC ESOPHAGITIS;
D O I：
10.1007/s11882-018-0785-7
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Purpose of Review The progression of atopic disorders from atopic dermatitis in infants to allergic rhinitis and asthma in children, adolescents, and adults defines the allergy march. Allergen immunotherapy is the only causal treatment altering the immunological mechanism underlying the allergic diseases. The sublingual administration route is more acceptable than the subcutaneous one in pediatric age. Recent Findings Several studies show the efficacy and safety profile of sublingual immunotherapy (SLIT) for the treatment of respiratory allergy diseases, but few data are available on its effect of primary and secondary prevention of allergic disease. Summary The purpose of this manuscript is to review the latest studies addressing the effect of SLIT on the development of new sensitizations in not sensitized or already sensitized patients and progression of the allergy march.
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页数：11
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