The Role of MicroRNAs in Diabetic Nephropathy

被引：59

作者：

Wu, Hao ^{[1
,2
,3
]}

Kong, Lili ^{[1
,3
]}

Zhou, Shanshan ^{[3
,4
]}

Cui, Wenpeng ^{[1
]}

Xu, Feng ^{[1
]}

Luo, Manyu ^{[1
,3
]}

Li, Xiangqi ^{[5
]}

Tan, Yi ^{[2
,3
]}

Miao, Lining ^{[1
]}

机构：

[1] Jilin Univ, Hosp 2, Dept Nephrol, Changchun 130041, Peoples R China

[2] Wenzhou Med Univ, Chinese Amer Res Inst Diabet Complicat, Wenzhou 325035, Peoples R China

[3] Univ Louisville, Kosair Childrens Hosp Res Inst, Dept Pediat, Louisville, KY 40202 USA

[4] Jilin Univ, Cardiovasc Ctr, Hosp 1, Changchun 130021, Peoples R China

[5] Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China

来源：

JOURNAL OF DIABETES RESEARCH | 2014年 / 2014卷

基金：

美国国家科学基金会;

关键词：

NF-KAPPA-B; INDUCED COLLAGEN EXPRESSION; GROWTH-FACTOR; RENAL FIBROSIS; HEPATOCELLULAR-CARCINOMA; UP-REGULATION; FIBRONECTIN EXPRESSION; MESANGIAL HYPERTROPHY; THERAPEUTIC TARGET; PROMOTES APOPTOSIS;

D O I：

10.1155/2014/920134

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetic nephropathy (DN), as one of the chronic complications of diabetes, is the major cause of end-stage renal disease. However, the pathogenesis of this disease is not fully understood. In recent years, research on microRNAs (miRNAs) has become a hotspot because of their critical role in regulating posttranscriptional levels of protein-coding genes that may serve as key pathogenic factors in diseases. Several miRNAs were found to participate in the pathogenesis of DN, while others showed renal protective effects. Therefore, targeting miRNAs that are involved in DN may have a good prospect in the treatment of the disease. The aim of this review is to summarize DN-related miRNAs and provide potential targets for diagnostic strategies and therapeutic intervention.

引用

页数：12

共 50 条

[41] MicroRNAs and Diabetic Complications
Natarajan, Rama
Putta, Sumanth
Kato, Mitsuo
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 2012, 5 (04) : 413 - 422
[42] The imminent role of microRNAs in salivary adenoid cystic carcinoma
Kumar, Pawan
Kumawat, Ram Kumar
Uttam, Vivek
Behera, Alisha
Rani, Medha
Singh, Neha
Barwal, Tushar Singh
Sharma, Uttam
Jain, Aklank
TRANSLATIONAL ONCOLOGY, 2023, 27
[43] Role of MicroRNAs-221/222 in Digestive Systems
Matsuzaki, Juntaro
Suzuki, Hidekazu
JOURNAL OF CLINICAL MEDICINE, 2015, 4 (08): : 1566 - 1577
[44] MicroRNAs: potential mediators and biomarkers of diabetic complications
Kato, Mitsuo
Castro, Nancy E.
Natarajan, Rama
FREE RADICAL BIOLOGY AND MEDICINE, 2013, 64 : 85 - 94
[45] Stem cell-derived and circulating exosomal microRNAs as new potential tools for diabetic nephropathy management
Peng, Lei
Chen, Yu
Shi, Shaoqing
Wen, Heling
STEM CELL RESEARCH & THERAPY, 2022, 13 (01)
[46] The Role of MicroRNAs in Diabetic Complications-Special Emphasis on Wound Healing
Moura, Joao
Borsheim, Elisabet
Carvalho, Eugenia
GENES, 2014, 5 (04) : 926 - 956
[47] The role of microRNAs in liver cancer
Papaconstantinou, Ioannis
Karakatsanis, Andreas
Gazouli, Maria
Polymeneas, George
Voros, Dionissios
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2012, 24 (03) : 223 - 228
[48] Potential Role of N-Cadherin in Diagnosis and Prognosis of Diabetic Nephropathy
Ali, Hamad
Abu-Farha, Mohamed
Hammad, Maha M.
Devarajan, Sriraman
Bahbahani, Yousif
Al-Khairi, Irina
Cherian, Preethi
Alsairafi, Zahra
Vijayan, Vidya
Al-Mulla, Fahd
Attar, Abdulnabi Al
Abubaker, Jehad
FRONTIERS IN ENDOCRINOLOGY, 2022, 13
[49] The role of TGF-β and epithelial-to mesenchymal transition in diabetic nephropathy
Hills, Claire E.
Squires, Paul E.
CYTOKINE & GROWTH FACTOR REVIEWS, 2011, 22 (03) : 131 - 139
[50] Microbubbles and Ultrasound: Therapeutic Applications in Diabetic Nephropathy
Cao, Wei J.
Matkar, Pratiek N.
Chen, Hao H.
Mofid, Azadeh
Leong-Poi, Howard
THERAPEUTIC ULTRASOUND, 2016, 880 : 309 - 330

← 1 2 3 4 5 →