The Role of MicroRNAs in Diabetic Nephropathy

被引：59

作者：

Wu, Hao ^{[1
,2
,3
]}

Kong, Lili ^{[1
,3
]}

Zhou, Shanshan ^{[3
,4
]}

Cui, Wenpeng ^{[1
]}

Xu, Feng ^{[1
]}

Luo, Manyu ^{[1
,3
]}

Li, Xiangqi ^{[5
]}

Tan, Yi ^{[2
,3
]}

Miao, Lining ^{[1
]}

机构：

[1] Jilin Univ, Hosp 2, Dept Nephrol, Changchun 130041, Peoples R China

[2] Wenzhou Med Univ, Chinese Amer Res Inst Diabet Complicat, Wenzhou 325035, Peoples R China

[3] Univ Louisville, Kosair Childrens Hosp Res Inst, Dept Pediat, Louisville, KY 40202 USA

[4] Jilin Univ, Cardiovasc Ctr, Hosp 1, Changchun 130021, Peoples R China

[5] Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China

来源：

JOURNAL OF DIABETES RESEARCH | 2014年 / 2014卷

基金：

美国国家科学基金会;

关键词：

NF-KAPPA-B; INDUCED COLLAGEN EXPRESSION; GROWTH-FACTOR; RENAL FIBROSIS; HEPATOCELLULAR-CARCINOMA; UP-REGULATION; FIBRONECTIN EXPRESSION; MESANGIAL HYPERTROPHY; THERAPEUTIC TARGET; PROMOTES APOPTOSIS;

D O I：

10.1155/2014/920134

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetic nephropathy (DN), as one of the chronic complications of diabetes, is the major cause of end-stage renal disease. However, the pathogenesis of this disease is not fully understood. In recent years, research on microRNAs (miRNAs) has become a hotspot because of their critical role in regulating posttranscriptional levels of protein-coding genes that may serve as key pathogenic factors in diseases. Several miRNAs were found to participate in the pathogenesis of DN, while others showed renal protective effects. Therefore, targeting miRNAs that are involved in DN may have a good prospect in the treatment of the disease. The aim of this review is to summarize DN-related miRNAs and provide potential targets for diagnostic strategies and therapeutic intervention.

引用

页数：12

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