Design of granulatimide and isogranulatimide analogues as potential Chk1 inhibitors: Study of amino-platforms for their synthesis

被引：29
作者：
Lavrard, Hubert [1 ]
Rodriguez, Frederic [1 ]
Delfourne, Evelyne [1 ]
机构：
[1] Univ Toulouse 3, CNRS, UMR 5068, Lab Synth & Physicochim Mol Interet Biol, F-31062 Toulouse 9, France
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2014年 / 22卷 / 17期
关键词：
Marine alkaloid; Isogranulatimide; Granulatimide; Chk1; inhibitors; MARINE ALKALOIDS GRANULATIMIDE; CHECKPOINT KINASE 1; IDENTIFICATION; DOCKING; 3D-QSAR;
D O I：
10.1016/j.bmc.2014.06.028
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The two marine alkaloids granulatimide and isogranulatimide have been shown to inhibit the checkpoint kinase 1 (Chk1), a promising target for cancer treatment. A molecular docking study allowing the design of new potential Chk1 inhibitors based on the natural products skeleton and the synthetic work to an amino-target platform to prepare them are described. (C) 2014 Elsevier Ltd. All rights reserved.
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收藏
页码：4961 / 4967
页数：7
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