The influence of folate pathway polymorphisms on high-dose methotrexaterelated toxicity and survival in children with non-Hodgkin malignant lymphoma

被引：15

作者：

Erculj, Nina ^{[1
]}

Kotnik, Barbara Faganel ^{[2
]}

Debeljak, Marusa ^{[3
]}

Jazbec, Janez ^{[2
]}

Dolzan, Vita ^{[1
]}

机构：

[1] Univ Ljubljana, Fac Med, Inst Biochem, Pharmacogenet Lab, Ljubljana 1000, Slovenia

[2] Univ Med Ctr, Univ Childrens Hosp, Dept Hematol & Oncol, Ljubljana, Slovenia

[3] Univ Med Ctr, Univ Childrens Hosp, Ctr Med Genet, Ljubljana, Slovenia

来源：

RADIOLOGY AND ONCOLOGY | 2014年 / 48卷 / 03期

关键词：

childhood; non-Hodgkin lymphoma; folate pathway; polymorphism; high-dose methotrexate; toxicity; ACUTE LYMPHOBLASTIC-LEUKEMIA; METABOLIC PATHWAY; THERAPY; ASSOCIATION;

D O I：

10.2478/raon-2013-0076

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background. We evaluated the influence of folate pathway polymorphisms on high-dose methotrexate (HD-MTX) related toxicity in paediatric patients with T-cell non-Hodgkin lymphoma (NHL). Patients and methods. In total, 30 NHL patients were genotyped for selected folate pathway polymorphisms. Results. Carriers of at least one MTHFR 677T allele had significantly higher MTX area under the time-concentration curve levels at third MTX cycle (P = 0.003). These patients were also at higher odds of leucopoenia (P = 0.006) or thrombocytopenia (P = 0.041) and had higher number of different HD-MTX-related toxicity (P = 0.035) compared to patients with wild-type genotype. Conclusions. Our results suggest an important role of MTHFR 677C>T polymorphism in the development of HD-MTX-related toxicity in children with NHL.

引用

页码：289 / 292

页数：4

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