Lack of evidence for association between serotonin transporter gene (5-HTTLPR) and obsessive-compulsive disorder by case control and family association study in humans

被引：40
作者：
Chabane, N
Millet, B
Delorme, R
Lichtermann, D
Mathieu, F
Laplanche, JL
Roy, I
Mouren, MC
Hankard, R
Maier, W
Launay, JM
Leboyer, M
机构：
[1] Hop Robert Debre, Serv Psychopathol Enfant & Adolescent, Assistance Publ Hop Paris, F-75019 Paris, France
[2] Hop Robert Debre, Ctr Invest Clin, Assistance Publ Hop Paris, F-75019 Paris, France
[3] Hop Henri Mondor & Albert Chenevier, Psychiat Serv, Assistance Publ Hop Paris, F-94010 Creteil, France
[4] Hop Lariboisiere, Assistance Publ Hop Paris, Cent Biochim Lab, F-75475 Paris, France
[5] Univ Bonn, Dept Psychiat, D-53105 Bonn, Germany
[6] Univ Paris, INSERM E0 117, Dept Psychiat, St Anne Hosp, F-75674 Paris, France
[7] Hop Henri Mondor, Lab Neurobiol & Psychiat, INSERM U513, F-94010 Creteil, France
来源：
NEUROSCIENCE LETTERS | 2004年 / 363卷 / 02期
关键词：
serotonin transporter gene; obsessive-compulsive disorder; case control; family study;
D O I：
10.1016/j.neulet.2004.03.065
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Association studies of the serotonin transporter (SLC6A4) gene in obsessive-compulsive disorder (OCD) have generated discrepant results. Here, we genotyped the 5-HTTLPR polymorphism in 106 French OCD patients and 171 healthy controls (case control study). We also performed a family association study on 116 trios including an OCD patient (73 French and 43 German). No association was detected between the 5-HTTLPR polymorphism and OCD in either the case control study or the family study. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：154 / 156
页数：3
相关论文
共 22 条
  • [1] Alsobrook JP, 1999, AM J MED GENET, V88, P669, DOI 10.1002/(SICI)1096-8628(19991215)88:6<669::AID-AJMG17>3.0.CO
  • [2] 2-N
  • [3] THE GENETICS OF 6 NEUROTIC DISORDERS - A TWIN STUDY
    ANDREWS, G
    STEWART, G
    ALLEN, R
    HENDERSON, AS
    [J]. JOURNAL OF AFFECTIVE DISORDERS, 1990, 19 (01) : 23 - 29
  • [4] Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder
    Bengel, D
    Greenberg, BD
    Corá-Locatelli, G
    Altemus, M
    Heils, A
    Li, Q
    Murphy, DL
    [J]. MOLECULAR PSYCHIATRY, 1999, 4 (05) : 463 - 466
  • [5] Obsessive compulsive disorder, response to serotonin reuptake inhibitors and the serotonin transporter gene
    Billett, EA
    Richter, MA
    King, N
    Heils, A
    Lesch, KP
    Kennedy, JL
    [J]. MOLECULAR PSYCHIATRY, 1997, 2 (05) : 403 - 406
  • [6] Camarena B, 2001, INT J NEUROPSYCHOPH, V4, P269, DOI 10.1017/S1461145701002516
  • [7] Exploratory factor analysis of obsessive-compulsive patients and association with 5-HTTLPR polymorphism
    Cavallini, MC
    Di Bella, D
    Siliprandi, F
    Malchiodi, F
    Bellodi, L
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS, 2002, 114 (03): : 347 - 353
  • [8] Obsessive-compulsive disorder, 5-HTTLPR polymorphism and treatment response
    Di Bella D.
    Erzegovesi S.
    Cavallini M.C.
    Bellodi L.
    [J]. The Pharmacogenomics Journal, 2002, 2 (3) : 176 - 181
  • [9] Association between obsessive-compulsive disorder and polymorphisms of genes encoding components of the serotonergic and dopaminergic pathways
    Frisch, A
    Michaelovsky, E
    Rockah, R
    Amir, I
    Hermesh, H
    Laor, N
    Fuchs, C
    Zohar, J
    Lerer, B
    Buniak, SF
    Landa, S
    Poyurovsky, M
    Shapira, B
    Weizman, R
    [J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2000, 10 (03) : 205 - 209
  • [10] Heils A, 1996, J NEUROCHEM, V66, P2621
123