Axinelline A, a new COX-2 inhibitor from Streptomyces axinellae SCSIO02208

被引：22

作者：

Ai, Wen ^{[1
,2
]}

Lin, Xiu-Ping ^{[1
]}

Tu, Zhengchao ^{[3
]}

Tian, Xin-Peng ^{[1
]}

Lu, Xin ^{[3
]}

Mangaladoss, Fredimoses ^{[1
]}

Zhong, Zhi-Long ^{[1
,2
]}

Liu, Yonghong ^{[1
]}

机构：

[1] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, State Key Lab Resp Dis, Guangzhou 510530, Guangdong, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2014年 / 28卷 / 16期

基金：

中国国家自然科学基金;

关键词：

Streptomyces axinellae; COX-2; inhibitor; GRISEUS;

D O I：

10.1080/14786419.2014.891204

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Axinelline A, a new cyclooxygenase-2 (COX-2) inhibitor, was isolated from Streptomyces axinellae SCSIO02208. The structures of compounds 1-9 were determined by analysing the NMR and MS data. The absolute configuration of 1 was determined by using optical rotation and comparing with the reported data. Compound 1 exhibited COX-2 inhibitory activity, the IC50 value being 2.8 mu M.

引用

收藏

页码：1219 / 1224

页数：6

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