A selective glucose sensor: the cooperative effect of monoboronic acid-modified poly(amidoamine) dendrimers

被引：12
|
作者：
Tsai, Ching-Hua [1 ]
Tang, Yi-Hsuan [1 ]
Chen, Hui-Ting [2 ,4 ]
Yao, Yi-Wen [1 ]
Chien, Tun-Cheng [3 ]
Kao, Chai-Lin [1 ,4 ,5 ]
机构：
[1] Kaohsiung Med Univ, Dept Med & Appl Chem, Kaohsiung 807, Taiwan
[2] Kaohsiung Med Univ, Dept Fragrance & Cosmet Sci, Kaohsiung 807, Taiwan
[3] Natl Taiwan Normal Univ, Dept Chem, Taipei 116, Taiwan
[4] Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung 807, Taiwan
[5] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 36期
关键词：
BORONIC ACID; AFFINITY; NANOPARTICLES; ENRICHMENT; BIOSENSORS; COMPLEXES; HYDROGELS;
D O I：
10.1039/c8cc00914g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Selective glucose binding was identified through five generations of monoboronic acid-functionalized PAMAM dendrimers. The best selectivity obtained when using G3 dendrimers (1b) generated 71.1, 94.9, and 1309 times stronger binding than when using galactose, fructose, and lactose, respectively. Further experiments using dendrimer analogues and glucose derivatives suggested that two nearby monoboronic acids cooperatively bound one glucose.
引用
收藏
页码：4577 / 4580
页数：4
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