Synthesis of 2-N/S/C-Substituted Benzothiazoles via Intramolecular Cyclative Cleavage of Benzotriazole Ring

被引：58

作者：

Kumar, Dhananjay ^{[1
]}

Mishra, Bhuwan B. ^{[1
]}

Tiwari, Vinod K. ^{[1
]}

机构：

[1] Banaras Hindu Univ, Fac Sci, Dept Chem, Ctr Adv Study, Varanasi 221005, Uttar Pradesh, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 01期

关键词：

ABSOLUTE RATE CONSTANTS; TRIETHYLSILYL RADICALS; ONE-POT; SUBSTITUTED BENZOTHIAZOLES; ORGANIC-SYNTHESIS; HIGHLY EFFICIENT; FACILE SYNTHESIS; DERIVATIVES; BENZIMIDAZOLES; DEOXYGENATION;

D O I：

10.1021/jo4024107

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of numerous 2-N/S/C-substituted benzothiazoles was achieved from substituted thiocarbonylbenzotriazoles via free-radical intramolecular cyclative cleavage of the benzotriazole ring in the presence of (TMS)(3)SiH and AIBN under mild conditions. The developed methodology demonstrates significant compatibility under microwave conditions and is important as it avoids the use of toxic metals for radical cyclization.

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页码：251 / 266

页数：16

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