Synthesis and antibacterial activity of derivatives of the glycopeptide antibiotic A-40926 and its aglycone

被引：9

作者：

Hermann, R

Ripamonti, F

Romano, G

Restelli, E

Ferrari, P

Goldstein, BP

Berti, M

Ciabatti, R

机构：

[1] LEPETIT RES CTR,I-21040 GERENZANO,VARESE,ITALY

[2] APPL MICROBIOL INC,NEW YORK,NY

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 12期

关键词：

D O I：

10.7164/antibiotics.49.1236

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Starting from the antibiotic A-40926 and the aglycone of A-40926 a series of compounds were prepared by modifying the free functionalities. Their antimicrobial activity was determined, particularly against Neisseria gonorrhoeae, against which A-40926, unlike other natural glycopeptides, is active. Improved in vivo activity was displayed by the monomethyl ester of A-40926 esterified at the carboxyl group of the N-acylamino-glucuronyl moiety.

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页码：1236 / 1248

页数：13

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