Dialytic nutrition: Provision of amino acids in dialysate during hemodialysis

被引:34
作者
Chazot, C
Shahmir, E
Matias, B
Laidlaw, S
Kopple, JD
机构
[1] HARBOR UCLA MED CTR,SCH MED,DIV ONCOL,LOS ANGELES,CA
[2] HARBOR UCLA MED CTR,SCH PUBL HLTH,LOS ANGELES,CA
[3] HARBOR UCLA MED CTR,SCH MED,DIV NEPHROL & HYPERTENS,LOS ANGELES,CA
关键词
amino acids in dialysate; hemodialysis; nutrition; morbidity and mortality; dialysate;
D O I
10.1038/ki.1997.500
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Maintenance hemodialysis (MHD) patients are frequently malnourished, a condition associated with high morbidity and mortality. Amino acid (AA) losses in dialysate may enhance protein malnutrition in patients with low food intake. We studied the possibility of providing AA in dialysate during MHD to either prevent AA losses or as a nutritional supplement. Six clinically stable men were studied during three hemodialysis treatments. The first treatment was performed using the usual dialysate (0XAA). The two other treatments were performed using a dialysate containing an amount of AA equal to normal plasma AA concentrations (1XAA) or to three times the normal plasma AA concentrations (3XAA). During the OXAA treatment, the total AA losses were 10.0 +/- 0.9 (SEM) grams (g) and the total AA concentrations in plasma decreased by 49 +/- 4%. During the 1XAA treatment, the total AA balance was +0.8 +/- 1.8 g and there was no significant change in the postdialysis plasma total AA. With the 3XAA treatment, the patients gained 36.9 +/- 4.1 g of AA during the hemodialysis treatment and the plasma total AA levels increased by 45 +/- 9%. No side effects were observed. These findings indicate that it may be feasible to provide AA supplements to MHD patients by adding AA to hemodialysate.
引用
收藏
页码:1663 / 1670
页数:8
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