The Counseling and Management of Young Healthy BRCA Mutation Carriers

被引：8

作者：

Eitan, Ram ^{[1
,2
]}

Michaelson, Rachel ^{[3
]}

Levavi, Hanoch ^{[1
,2
]}

Beller, Uziel ^{[3
]}

机构：

[1] Helen Schneider Hosp Women, Rabin Med Ctr, Petah Tiqwa, Israel

[2] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel

[3] Hebrew Univ Jerusalem, Hadassah Med Sch, Shaare Zedek Med Ctr, Dept Obstet & Gynecol, IL-91010 Jerusalem, Israel

来源：

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER | 2009年 / 19卷 / 07期

关键词：

BRCA; Healthy mutation carriers; Counseling; ORAL-CONTRACEPTIVE USE; OVARIAN-CANCER RISK; BREAST-CANCER; AGE; OOPHORECTOMY; NONCARRIERS; PREGNANCY; COHORT; BIRTH; 1ST;

D O I：

10.1111/IGC.0b013e3181b33c4a

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although more than 15 years have elapsed since the discovery of the BRCA1 and BRCA2 genes and the associated increased risk of breast and ovarian cancers in mutation carriers, our understanding of the syndrome is still evolving. With the accumulation of knowledge, more questions arise regarding the proper approach to mutation carriers diagnosed as having cancer. Moreover, the number of questions regarding the recommended management methods for healthy carriers and the potential risk-reducing measures is increasing constantly. In this review, we discuss these issues and summarize contemporary recommendations.

引用

页码：1156 / 1159

页数：4

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